Results 91 to 100 of about 534,909 (297)

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Analyzing outcomes following pancreas transplantation: Definition of a failure or failure of a definition

, 2022
Pancreas transplantation has an identity crisis and is at a crossroads. Although outcomes continue to improve in each successive era, the number of pancreas transplants performed annually in the United States has been static for several years in spite of
Stratta, Robert J., Fridell, Jonathan A., Farney, Alan C.   +2 more
core   +1 more source

The natural killer–cellular humoral activation test as a functional biomarker of antibody-mediated rejection after kidney transplantation

Scientific Reports
Antibody-mediated rejection (ABMR) is a major cause of graft failure after kidney transplantation, yet current diagnostics do not directly assess effector immune activity.
Jin-Myung Kim, So Hyeon Yun, Hye Eun Kwon, Youngmin Ko, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Hun Sik Kim, Sung Shin   +8 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Successful treatment for graft‐versus‐host disease after pancreas transplantation

, 2014
Graft-versus-host disease (GVHD) after pancreas transplantation is a rare but serious complication: All previously reported cases were fatal. We herein report three cases of GVHD after pancreas transplantation with favorable outcomes.
Chang, Jei wen, Jei wen Chang, Burke, 3rd, George W, Adela Mattiazzi, Hsin‐Lin Tsai, Chen, Linda, Ruiz, Phillip, Ciancio, Gaetano, Junichiro Sageshima, Sageshima, Junichiro, Linda Chen, Gaetano Ciancio, Tsai, Hsin-Lin, George W. Burke, Phillip Ruiz, Mattiazzi, Adela   +15 more
core   +1 more source

Noradrenergic and Cholinergic Reinnervation of Islet Grafts in Diabetic Rats [PDF]

, 1996
Grafted islets become denervated due to the islet transplantation procedure. The aim of the present study was 1) to examine whether islet grafts in the liver, the spleen, and under the kidney capsule in rats become reinnervated following the ...
Oestreicher, AB, Strubbe, JH, van der Zee, E A, Suylichem, Paul T.R. van,, Oestreicher, A B, Asperen, Roelie M. van,, Strubbe, Jan H.,, VanAsperen, RM, Steffens, Anton B.,, Houwing, H, van Suylichem, P T R, Eddy A. Van Der Zee, Steffens, AB, Zee, Eddy A. van der,, Harmina Houwing, VanderZee, EA, Strubbe, J H, Houwing, Harmina,, van Asperen, R M, Oestreicher, A. Beate,, Jan H. Strubbe, Van Suylichem, PTR, Paul T.R. Van Suylichem, Steffens, A B, Roelie M. Van Asperen, Asperen, Roelie M. van, A. Beate Oestreicher, Anton B. Steffens   +27 more
core   +1 more source

Impact of IgG monitoring and machine learning based prediction on outcomes of ABO incompatible kidney transplantation in blood type O recipients

Scientific Reports
ABO-incompatible kidney transplantation (ABO-i KT) facilitates transplantation across blood types; however, antibody-mediated rejection (ABMR) remains a major concern, particularly in blood type O recipients. This retrospective study evaluated the effect
Youngmin Ko, Jin-Myung Kim, Hye Eun Kwon, Sung Shin, Joo Hee Jung, Young Hoon Kim, Juhan Lee, Dae-Hyun Ko, Hyunwook Kwon   +8 more
doaj   +1 more source

Bowel complications requiring surgical intervention in kidney transplant recipients: a retrospective study of clinical characteristics and risk factors

Clinical Transplantation and Research
Background : Bowel complications following kidney transplantation (KT) are rare but life-threatening, often necessitating bowel resection. These complications are associated with immunosuppressive therapy, comorbidities, and viral infections.
Jin-Myung Kim, Tuan Thanh Nguyen, Hye Eun Kwon, Youngmin Ko, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Sung Shin   +7 more
doaj   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source