Results 71 to 80 of about 534,909 (297)

Current Status of Pancreas Transplantation

, 2014
Transplantation of whole pancreas can restore euglycemia in patients with insulin-dependent, type 1 diabetes (T1D). It reverses diabetes in most patients, improving complications and quality of life, but requires chronic immunosuppression. Given the side
Ciancio, Gaetano, Junichiro Sageshima, Burke, George W, Sageshima, Junichiro, Pugliese, Alberto, Chen, Linda, Linda Chen, Gaetano Ciancio, Alberto Pugliese, George W. Burke   +9 more
core   +1 more source

The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential Antioxidant Effect

Antioxidants
Imbalances in the redox state of the liver arise during metabolic processes, inflammatory injuries, and proliferative liver disorders. Acute exposure to intracellular reactive oxygen species (ROS) results from high levels of oxidative stress (OxS) that ...
Siyuan Yao, Aanchal Kasargod, Richard Chiu, Taylor R. Torgerson, Jerzy W. Kupiec-Weglinski, Kenneth J. Dery   +5 more
doaj   +1 more source

Demographic profile in liver transplant candidates on waiting list

Brazilian Journal of Transplantation, 2010
Liver transplantation is a life-saving therapy for patients with end-stage liver diseases. The post-transplant outcome depends on a wide knowledge of the patient's status and factors that may influence results and complications, as well as an ...
Camila César Winckler, Daniela Salate Biagioni, Regina Célia Callile de Paula, Milene Regina Bailo Gomes, Juan Carlos Llanos, Alexandre Bakonyi Neto, Giovanni Faria Silva, Ricardo Augusto Monteiro de Barros Almeida, Rodrigo Jose Polônio   +8 more
doaj   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child

, 2020
BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise.
Fischler, Björn, Sandberg, John, Nordström, Johan, Wennberg, Lars,, Jorns, Carl, Nowak, Greg,, Fischler, Björn,, Arnell, Henrik, Dlugosz, Rafal,, Nordström, Johan,, Arnell, Henrik,, Dlugosz, Rafal, Sandberg, John,, Wennberg, Lars, Nowak, Greg, Lundgren, Markus,, Lund University., Lundgren, Markus, Jorns, Carl,   +18 more
core   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Pathophysiology of ascites: The importance of the intestine. A surgical contribution to the understanding of a medical problem

Annals of Hepatology
The understanding of the mechanisms for the development of ascites has evolved over the years, involving the liver, peritoneum, heart, and kidneys as key responsible for its formation.
Gabriel E. Gondolesi, Carolina Rumbo, Leonardo Montes, Lucia Novellis, Diego Ramisch, Ariel Riquelme Henríquez, Mariana Ortega, Federico Viano, Thomas Schiano, Valeria Descalzi, Claudio Tiribelli, Mihai Oltean, Pablo Barros-Schelotto, Héctor Solar   +13 more
doaj   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source