Results 71 to 80 of about 64,532 (302)

Current Status of Pancreas Transplantation

, 2014
Transplantation of whole pancreas can restore euglycemia in patients with insulin-dependent, type 1 diabetes (T1D). It reverses diabetes in most patients, improving complications and quality of life, but requires chronic immunosuppression. Given the side
Ciancio, Gaetano, Junichiro Sageshima, Burke, George W, Sageshima, Junichiro, Pugliese, Alberto, Chen, Linda, Linda Chen, Gaetano Ciancio, Alberto Pugliese, George W. Burke   +9 more
core   +1 more source

First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child

, 2020
BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise.
Fischler, Björn, Sandberg, John, Nordström, Johan, Wennberg, Lars,, Jorns, Carl, Nowak, Greg,, Fischler, Björn,, Arnell, Henrik, Dlugosz, Rafal,, Nordström, Johan,, Arnell, Henrik,, Dlugosz, Rafal, Sandberg, John,, Wennberg, Lars, Nowak, Greg, Lundgren, Markus,, Lund University., Lundgren, Markus, Jorns, Carl,   +18 more
core   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential Antioxidant Effect

Antioxidants
Imbalances in the redox state of the liver arise during metabolic processes, inflammatory injuries, and proliferative liver disorders. Acute exposure to intracellular reactive oxygen species (ROS) results from high levels of oxidative stress (OxS) that ...
Siyuan Yao, Aanchal Kasargod, Richard Chiu, Taylor R. Torgerson, Jerzy W. Kupiec-Weglinski, Kenneth J. Dery   +5 more
doaj   +1 more source

Kidney and pancreas transplantation

American Journal of Transplantation, 2004
Data from the Scientific Registry of Transplant Recipients offer a unique and comprehensive view of US trends in kidney and pancreas waiting list characteristics and outcomes, transplant recipient and donor characteristics, and patient and allograft survival.
Wynn, James J., Distant, Dale A., Pirsch, John D., Norman, Douglas, Gaber, A. Osama, Ashby, Valarie B., Leichtman, Alan B.   +6 more
openaire   +3 more sources

Intestinal Obstruction Due to Internal Hernia Following Pancreas Transplantation

, 2010
Background. Simultaneous pancreas-kidney transplantation has evolved as the best treatment for type 1 diabetic patients at end-stage renal disease. the surgical complication rate is high, which is an important barrier to the success of this procedure ...
Matos, D. [UNIFESP], Sa, J. R. [UNIFESP], Melaragno, C. [UNIFESP], Rangel, E. [UNIFESP], del Grande, L. [UNIFESP], Medina Pestana, J. O. [UNIFESP], Salzedas, A. [UNIFESP], Vicentine, F. P. [UNIFESP], Lopes-Filho, G. J. [UNIFESP], Sousa, Marcelo Goncalves [UNIFESP], Linhares, M. M. [UNIFESP], Gonzalez, A. [UNIFESP]   +11 more
core   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Risk indices predicting graft use, graft and patient survival in solid pancreas transplantation: a systematic review

BMC Gastroenterology, 2021
Background Risk indices such as the pancreas donor risk index (PDRI) and pre-procurement pancreas allocation suitability score (P-PASS) are utilised in solid pancreas transplantation however no review has compared all derived and validated indices in ...
Jonathan E. H. Ling, Timothy Coughlan, Kevan R. Polkinghorne, John Kanellis   +3 more
doaj   +1 more source