Results 51 to 60 of about 59,170 (258)

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential Antioxidant Effect

Antioxidants
Imbalances in the redox state of the liver arise during metabolic processes, inflammatory injuries, and proliferative liver disorders. Acute exposure to intracellular reactive oxygen species (ROS) results from high levels of oxidative stress (OxS) that ...
Siyuan Yao, Aanchal Kasargod, Richard Chiu, Taylor R. Torgerson, Jerzy W. Kupiec-Weglinski, Kenneth J. Dery   +5 more
doaj   +1 more source

Demographic profile in liver transplant candidates on waiting list

Brazilian Journal of Transplantation, 2010
Liver transplantation is a life-saving therapy for patients with end-stage liver diseases. The post-transplant outcome depends on a wide knowledge of the patient's status and factors that may influence results and complications, as well as an ...
Camila César Winckler, Daniela Salate Biagioni, Regina Célia Callile de Paula, Milene Regina Bailo Gomes, Juan Carlos Llanos, Alexandre Bakonyi Neto, Giovanni Faria Silva, Ricardo Augusto Monteiro de Barros Almeida, Rodrigo Jose Polônio   +8 more
doaj   +1 more source

Kidney and pancreas transplantation

American Journal of Transplantation, 2004
Data from the Scientific Registry of Transplant Recipients offer a unique and comprehensive view of US trends in kidney and pancreas waiting list characteristics and outcomes, transplant recipient and donor characteristics, and patient and allograft survival.
Wynn, James J., Distant, Dale A., Pirsch, John D., Norman, Douglas, Gaber, A. Osama, Ashby, Valarie B., Leichtman, Alan B.   +6 more
openaire   +3 more sources

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Pathophysiology of ascites: The importance of the intestine. A surgical contribution to the understanding of a medical problem

Annals of Hepatology
The understanding of the mechanisms for the development of ascites has evolved over the years, involving the liver, peritoneum, heart, and kidneys as key responsible for its formation.
Gabriel E. Gondolesi, Carolina Rumbo, Leonardo Montes, Lucia Novellis, Diego Ramisch, Ariel Riquelme Henríquez, Mariana Ortega, Federico Viano, Thomas Schiano, Valeria Descalzi, Claudio Tiribelli, Mihai Oltean, Pablo Barros-Schelotto, Héctor Solar   +13 more
doaj   +1 more source

Kidney and pancreas transplantation [PDF]

American Journal of Transplantation, 2003
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/71514/1/j.1600-6143.3.s4.7.x ...
Gaston, Robert S., Alveranga, Denise Y., Becker, Bryan N., Distant, Dale A., Held, Philip J., Bragg-Gresham, Jennifer L., Humar, Abhinav, Ting, Alan, Wynn, James J., Leichtman, Alan B.   +9 more
openaire   +3 more sources

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Risk indices predicting graft use, graft and patient survival in solid pancreas transplantation: a systematic review

BMC Gastroenterology, 2021
Background Risk indices such as the pancreas donor risk index (PDRI) and pre-procurement pancreas allocation suitability score (P-PASS) are utilised in solid pancreas transplantation however no review has compared all derived and validated indices in ...
Jonathan E. H. Ling, Timothy Coughlan, Kevan R. Polkinghorne, John Kanellis   +3 more
doaj   +1 more source