Results 61 to 70 of about 64,532 (302)

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Sociodemographic factors and patient perceptions are associated with attitudes to kidney transplantation among haemodialysis patients

, 2008
Background. Treatment decisions made by patients with chronic kidney disease are crucial in the renal transplantation process. These decisions are influenced, amongst other factors, by attitudes towards different treatment options, which are modulated by
Marton, Adrienn, Novák, Márta, Zambo, Monika, Kovacs, Agnes, Réthelyi, János, Németh, Zsófia, Molnár, Miklós Zsolt, Csepanyi, Gabor, Vamos, Eszter Panna, Mucsi, István   +9 more
core   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

A comparative study on outcomes of ABO-incompatible kidney transplants between robot-assisted vs. open surgery-propensity score-matched analysis: a retrospective cohort study

BMC Nephrology
Background Robot-assisted kidney transplantation (RAKT) is increasingly being adopted worldwide. Despite this growing interest, there remains a notable gap in the literature, especially concerning its effectiveness in immunologically high-risk patients ...
Jin-Myung Kim, Hye Eun Kwon, Youngmin Ko, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Sung Shin   +6 more
doaj   +1 more source

Innovative strategies in kidney paired donation: single-center experience achieving the highest annual transplant volume globally

Frontiers in Immunology
BackgroundKidney Paired Donation (KPD) programs expand transplant opportunities for immunologically incompatible donor-recipient pairs. This study describes the operational framework and clinical outcomes of a high-volume, single-center KPD program ...
Khalid A. AlMeshari, Dieter C. Broering, Dalia A. Obeid, Ali N. AlAli, Amal N. Algharabli, Noreen L. Pana, Tariq Z. Ali   +6 more
doaj   +1 more source

Noradrenergic and Cholinergic Reinnervation of Islet Grafts in Diabetic Rats [PDF]

, 1996
Grafted islets become denervated due to the islet transplantation procedure. The aim of the present study was 1) to examine whether islet grafts in the liver, the spleen, and under the kidney capsule in rats become reinnervated following the ...
Oestreicher, AB, Strubbe, JH, van der Zee, E A, Suylichem, Paul T.R. van,, Oestreicher, A B, Asperen, Roelie M. van,, Strubbe, Jan H.,, VanAsperen, RM, Steffens, Anton B.,, Houwing, H, van Suylichem, P T R, Eddy A. Van Der Zee, Steffens, AB, Zee, Eddy A. van der,, Harmina Houwing, VanderZee, EA, Strubbe, J H, Houwing, Harmina,, van Asperen, R M, Oestreicher, A. Beate,, Jan H. Strubbe, Van Suylichem, PTR, Paul T.R. Van Suylichem, Steffens, A B, Roelie M. Van Asperen, Asperen, Roelie M. van, A. Beate Oestreicher, Anton B. Steffens   +27 more
core   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Demographic profile in liver transplant candidates on waiting list

Brazilian Journal of Transplantation, 2010
Liver transplantation is a life-saving therapy for patients with end-stage liver diseases. The post-transplant outcome depends on a wide knowledge of the patient's status and factors that may influence results and complications, as well as an ...
Camila César Winckler, Daniela Salate Biagioni, Regina Célia Callile de Paula, Milene Regina Bailo Gomes, Juan Carlos Llanos, Alexandre Bakonyi Neto, Giovanni Faria Silva, Ricardo Augusto Monteiro de Barros Almeida, Rodrigo Jose Polônio   +8 more
doaj   +1 more source

Kidney and pancreas transplantation [PDF]

American Journal of Transplantation, 2003
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/71514/1/j.1600-6143.3.s4.7.x ...
Gaston, Robert S., Alveranga, Denise Y., Becker, Bryan N., Distant, Dale A., Held, Philip J., Bragg-Gresham, Jennifer L., Humar, Abhinav, Ting, Alan, Wynn, James J., Leichtman, Alan B.   +9 more
openaire   +3 more sources