Results 11 to 20 of about 96,616 (294)

Pancreas transplantation

Surgery (Oxford), 2014
Pancreas transplantation is now standard of care for selected patients with diabetes and end-stage renal failure or life-threatening diabetic complications. The morbidity and mortality of pancreas transplantation is higher than other transplant types, and for this reason selection criteria for both donors and recipients are more stringent.
Knight, S, Vogel, T, Friend, P
openaire   +2 more sources

Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients [PDF]

, 1999
Objective: The effect of donor bone marrow was evaluated for its potentially favorable effect in the authors' simultaneous pancreas/kidney transplant program.
Abdul S. Rao, Carlos A. Vivas, Corry, Corry, Corry, Corry, Corry, Egidi, Fioretto, Fontes, Greussner, Gruessner, Igor Dvorchik, John J. Fung, Jordan, Kapur, Mark L. Jordan, Nghiem, Pinna, Pradip K. Chakrabarti, Rao, Robert J. Corry, Ron Shapiro, Scantlebury, Shapiro, Sollinger, Starzl, Starzl, Starzl, Sugitani, Thomas E. Starzl, Tyden, Tyden, Velma P. Scantlebury, Wakely, Zehr   +35 more
core   +2 more sources

Pancreas transplants

Clinical Radiology, 2009
Cadaveric, whole pancreas transplantation has proved an effective therapy in the treatment of long-standing type 1 diabetes mellitus and is capable of achieving an insulin-independent eugyclaemic state. As a result, this procedure is being increasingly performed. However, the surgical procedure is complex and unfamiliar to many radiologists.
Chandra, J, Phillips, R, Boardman, P, Gleeson, F, Anderson, E   +4 more
openaire   +3 more sources

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

Pancreas transplantation: review [PDF]

Einstein (São Paulo), 2015
ABSTRACT Vascularized pancreas transplantation is the only treatment that establishes normal glucose levels and normalizes glycosylated hemoglobin levels in type 1 diabetic patients. The first vascularized pancreas transplant was performed by William Kelly and Richard Lillehei, to treat a type 1 diabetes patient, in December 1966.
Meirelles Júnior, Roberto Ferreira, Salvalaggio, Paolo, Pacheco-Silva, Alvaro   +2 more
openaire   +6 more sources

Pancreas transplantation: an overview [PDF]

Einstein (São Paulo), 2010
ABSTRACT Pancreas transplantation is the only treatment able to reestablish normal glucose and glycated hemoglobin levels in insulin-dependent diabetic patients without the use of exogenous insulin. The evolution of pancreas transplantation in treatment of diabetes was determined by advances in the fields of surgical technique, organ preservation and ...
David, Andre Ibrahim, Ferraz-Neto, Ben-Hur, Levino, Fernando, Meirelles Junior, Roberto Ferreira, Silva Filho, Álvaro Pacheco e   +4 more
openaire   +7 more sources

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

Pancreas preservation for pancreas and islet transplantation [PDF]

Current Opinion in Organ Transplantation, 2008
To summarize advances and limitations in pancreas procurement and preservation for pancreas and islet transplantation, and review advances in islet protection and preservation.Pancreases procured after cardiac death, with in-situ regional organ cooling, have been successfully used for islet transplantation. Colloid-free Celsior and histidine-tryptophan-
James V. Harmon, Yasuhiro Iwanaga, David E.R. Sutherland, Klearchos K. Papas   +3 more
openaire   +4 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source