Results 71 to 80 of about 5,109,346 (334)

A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma

Journal for ImmunoTherapy of Cancer, 2019
Background Programmed cell death protein 1 (PD-1) is a key immune checkpoint that regulates peripheral tolerance and protects against autoimmunity.
Yiyin Zhang, Jin Xu, Jie Hua, Jiang Liu, Chen Liang, Qingcai Meng, Miaoyan Wei, Bo Zhang, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Journal of Hematology & Oncology, 2020
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to ...
Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi   +8 more
doaj   +1 more source

Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

Frontiers in Oncology, 2022
BackgroundThe neddylation pathway is aberrantly overactivated in multiple human cancers and has been indicated as an effective target for anticancer therapy in clinical trials.
Junfeng Xu, Junfeng Xu, Junfeng Xu, Junfeng Xu, Zheng Li, Zheng Li, Zheng Li, Zheng Li, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Zeng Ye, Zeng Ye, Zeng Ye, Zeng Ye, Guixiong Fan, Guixiong Fan, Guixiong Fan, Guixiong Fan, Heli Gao, Heli Gao, Heli Gao, Heli Gao, Shunrong Ji, Shunrong Ji, Shunrong Ji, Shunrong Ji, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wenyan Xu, Wenyan Xu, Wenyan Xu, Wenyan Xu   +43 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The microbiota and microbiome in pancreatic cancer: more influential than expected

Molecular Cancer, 2019
Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease for which mortality closely parallels ...
Miao-Yan Wei, Si Shi, Chen Liang, Qing-Cai Meng, Jie Hua, Yi-Yin Zhang, Jiang Liu, Bo Zhang, Jin Xu, Xian-Jun Yu   +9 more
doaj   +1 more source

Identification of the Roles of a Stemness Index Based on mRNA Expression in the Prognosis and Metabolic Reprograming of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundCancer stem cells (CSCs) are widely thought to contribute to the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC). CSCs share biological features with adult stem cells, such as longevity, self-renewal capacity, differentiation, drug ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source

Pancreatic Cancer [PDF]

CA: A Cancer Journal for Clinicians, 1981
As a result of increased funding in the past few years, carcinoma of the pancreas has received increased investigative attention. A substantial body of epidemiologic data has been recorded, which may ultimately provide leads that identify an "at risk" population.
R M, Beazley, I, Cohn
openaire   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective

Computational and Structural Biotechnology Journal, 2020
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is usually diagnosed at an advanced stage when curative surgery is no longer an option.
Wu-Hu Zhang, Wen-Quan Wang, Xuan Han, He-Li Gao, Tian-Jiao Li, Shuai-Shuai Xu, Shuo Li, Hua-Xiang Xu, Hao Li, Long-Yun Ye, Xuan Lin, Chun-Tao Wu, Jiang Long, Xian-Jun Yu, Liang Liu   +14 more
doaj  

Deciphering the Prognostic Implications of the Components and Signatures in the Immune Microenvironment of Pancreatic Ductal Adenocarcinoma

Frontiers in Immunology, 2021
Background: The treatment modalities for pancreatic ductal adenocarcinoma (PDAC) are limited and unsatisfactory. Although many novel drugs targeting the tumor microenvironment, such as immune checkpoint inhibitors, have shown promising efficacy for some ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source