Results 71 to 80 of about 409,500 (188)

NLRP4 renders pancreatic cancer resistant to olaparib through promotion of the DNA damage response and ROS-induced autophagy

Cell Death and Disease
Olaparib has been approved as a therapeutic option for metastatic pancreatic ductal adenocarcinoma patients with BRCA1/2 mutations. However, a significant majority of pancreatic cancer patients have inherent resistance or develop tolerance to olaparib ...
Mingming Xiao, Jing Yang, Mingwei Dong, Xiaoqi Mao, Haoqi Pan, Yalan Lei, Xuhui Tong, Xiaoning Yu, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source

Laparoscopic pancreaticoduodenectomy: are the best times coming?

World Journal of Surgical Oncology, 2019
Background The introduction of laparoscopic technology has greatly promoted the development of surgery, and the trend of minimally invasive surgery is becoming more and more obvious.
Mengqi Liu, Shunrong Ji, Wenyan Xu, Wensheng Liu, Yi Qin, Qiangsheng Hu, Qiqing Sun, Zheng Zhang, Xianjun Yu, Xiaowu Xu   +9 more
doaj   +1 more source

Autophagy in Pancreatic Cancer [PDF]

International Journal of Cell Biology, 2012
Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated.
Daniel Grasso, Maria Noé Garcia, Juan L. Iovanna   +2 more
openaire   +4 more sources

Pancreatic Cancer: Surgery of pancreatic cancer

Annals of Oncology, 1994
Pancreatic cancer which has an increasing incidence in the western countries is associated with an especially poor prognosis. This is mainly due to the low proportion of early and radically resectable stages, when diagnosed. Patients with irresectable disease have a median survival time of 3-4 months and their prognosis is not essentially improved by ...
openaire   +2 more sources

Laparoscopic repeat liver resection for hepatic epithelioid hemangioendothelioma

Surgical Case Reports, 2020
Background Optimal treatment for patients with hepatic epithelioid hemangioendothelioma (HEHE) remains unclear. Laparoscopic repeat liver resection (LR) is a minimally invasive and potentially effective surgical option for multiple HEHEs.
Fumihiro Terasaki, Yusuke Yamamoto, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Katsuhisa Ohgi, Katsuhiko Uesaka   +7 more
doaj   +1 more source

Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer

Experimental Hematology & Oncology, 2020
Background Pancreatic cancer continues to be one of the most aggressive malignant tumors. Work in recent years in cancer molecular biology has revealed that metabolic reprogramming is an additional hallmark of cancer that is involved in the pathogenesis ...
Mengqi Liu, Wensheng Liu, Yi Qin, Xiaowu Xu, Xianjun Yu, Qifeng Zhuo, Shunrong Ji   +6 more
doaj   +1 more source

MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine

Cancer Cell International, 2019
Background Methyl-CpG binding domain protein 1 (MBD1), which couples DNA methylation to transcriptional repression, has been implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell cycle progression and development ...
Liu Wensheng, Zhang Bo, Hu Qiangsheng, Xu Wenyan, Ji Shunrong, Xu Jin, Ni Quanxing, Yu Xianjun, Xu Xiaowu   +8 more
doaj   +1 more source

Feasibility of laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a retrospective cohort study

World Journal of Surgical Oncology
Background There is no evidence supporting the feasibility of laparoscopic pancreaticoduodenectomy (LPD) compared to open pancreatoduodenectomy (OPD) following neoadjuvant chemotherapy (NACT) for pancreatic ductal adenocarcinoma (PDAC).
Zheng Li, Qifeng Zhuo, Borui Li, Mengqi Liu, Chen Chen, Yihua Shi, Wenyan Xu, Wensheng Liu, Shunrong Ji, Xianjun Yu, Xiaowu Xu   +10 more
doaj   +1 more source

The role of collagen in cancer: from bench to bedside

Journal of Translational Medicine, 2019
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore ...
Shuaishuai Xu, Huaxiang Xu, Wenquan Wang, Shuo Li, Hao Li, Tianjiao Li, Wuhu Zhang, Xianjun Yu, Liang Liu   +8 more
doaj   +1 more source

Pancreatic function and the absorption of fat, iron, vitamin B12, and calcium after total gastrectomy for gastric cancer. [PDF]

, 1967
K Fischermann, S Harly, H. Worning, A Zacho   +3 more
openalex   +1 more source