Results 81 to 90 of about 5,109,346 (334)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Value of lymphadenectomy in patients with surgically resected pancreatic neuroendocrine tumors

BMC Surgery, 2022
Background Although some factors that predict the prognosis in pancreatic neuroendocrine tumor (pNET) have been confirmed, the predictive value of lymph node metastasis (LNM) in the prognosis of pNETs remains conflicting and it is not clear whether ...
Zheng Zhang, Fei Wang, Zheng Li, Zeng Ye, Qifeng Zhuo, Wenyan Xu, Wensheng Liu, Mengqi Liu, Guixiong Fan, Yi Qin, Yue Zhang, Xuemin Chen, Xianjun Yu, Xiaowu Xu, Shunrong Ji   +14 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Distinctive grade based on Ki67 index and immune microenvironment of metastatic pancreatic neuroendocrine tumors responding to capecitabine plus temozolomide

BMC Cancer
Background Ki67 index changes during the treatment of metastatic pancreatic neuroendocrine tumor (PanNET) treatment. The study aimed to detect alterations of grade based on Ki67 index and immune microenvironment in PanNET responding to capecitabine ...
Heli Gao, Wuhu Zhang, Zheng Li, Wensheng Liu, Mengqi Liu, Qifeng Zhuo, Yihua Shi, Wenyan Xu, Chenjie Zhou, Yi Qin, Jin Xu, Jie Chen, Xianjun Yu, Xiaowu Xu, Shunrong Ji   +14 more
doaj   +1 more source

A case of pancreatic head cancer with Trousseau’s syndrome treated with radical resection and anticoagulant therapy

Surgical Case Reports, 2023
Background The primary disease of Trousseau’s syndrome is often highly advanced cancer, and treatment of the primary disease after cerebral infarction is often difficult. We herein report a case of pancreatic head cancer with Trousseau’s syndrome treated
Takumi Kitahama, Shimpei Otsuka, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Katsuhiko Uesaka   +6 more
doaj   +1 more source

Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment

Technology in Cancer Research and Treatment, 2020
This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of pancreatic cancer, and aims to promote further research on this under-studied malignant tumor.
ZhiYu Zhao, Wei Liu
semanticscholar   +1 more source

Pancreatic cancer [PDF]

The Lancet, 2011
Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant ...
Audrey, Vincent, Joseph, Herman, Rich, Schulick, Ralph H, Hruban, Michael, Goggins   +4 more
openaire   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Topical application of Glauber’s salt accelerates the absorption of abdominal fluid after pancreatectomy

BMC Surgery
Background Abdominal fluid collection (AFC) is one of the most common complications after pancreatic surgery, yet there are few recommendations on how to manage it.
Jialin Li, Jie Hua, Haiyan Ruan, Hang Xu, Chen Liang, QingCai Meng, Jiang Liu, Bo Zhang, Jin Xu, Si Shi, XianJun Yu, Wei Wang   +11 more
doaj   +1 more source

Laparoscopic pancreaticoduodenectomy: are the best times coming?

World Journal of Surgical Oncology, 2019
Background The introduction of laparoscopic technology has greatly promoted the development of surgery, and the trend of minimally invasive surgery is becoming more and more obvious.
Mengqi Liu, Shunrong Ji, Wenyan Xu, Wensheng Liu, Yi Qin, Qiangsheng Hu, Qiqing Sun, Zheng Zhang, Xianjun Yu, Xiaowu Xu   +9 more
doaj   +1 more source