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Advanced Science, EarlyView.Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan +6 more
wiley +1 more source
Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
Advanced Science, EarlyView.FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao +8 more
wiley +1 more source
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Paediatric pancreatic diseases
Journal of Paediatrics and Child Health, 2020Paediatric pancreatic diseases are often under‐recognised and may be associated with severe diseases and significant clinical consequences. In recent years, advances have been made in key areas, particularly with the contributions from international societies and study groups focused on paediatric pancreatic disease research. This review focuses on the
Michael J Coffey, Chee Y Ooi
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Postgraduate Medicine, 1975
New tests and test methods aid in the diagnosis of pancreatic disorders. Pancreatic carcinoma, especially, may have an improved prognosis with earlier detection as a result of refinements in arteriography, cytology, pancreatic radioisotopic scanning, and endoscopic retrograde cholangiopancreatography.
E C, Kafka, M H, Kalser
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New tests and test methods aid in the diagnosis of pancreatic disorders. Pancreatic carcinoma, especially, may have an improved prognosis with earlier detection as a result of refinements in arteriography, cytology, pancreatic radioisotopic scanning, and endoscopic retrograde cholangiopancreatography.
E C, Kafka, M H, Kalser
openaire +2 more sources
Pancreatic Enzyme Synthesis in Pancreatic Disease
Scandinavian Journal of Gastroenterology, 1985In a prospective evaluation of patients suspected of having chronic pancreatitis, synthesis of pancreatic enzymes was measured by means of the incorporation of selenium-75-labelled methionine into the proteins of duodenal aspirate during stimulation of pancreatic secretion with secretin (1 CU X kg-1 X h-1) plus cholecystokinin (CCK) (1 IDU X kg-1 X h-1)
E J, Boyd +3 more
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2018
Acute pancreatitis is an acute inflammatory process of the pancreas and is potentially reversible. It is characterized by oedema and necrosis of peripancreatic fat and may progress to necrosis of glandular and surrounding tissue. Activation of pancreatic enzymes leads to pancreatic autodigestion and systemic effects.
Satish Keshav, Alexandra Kent
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Acute pancreatitis is an acute inflammatory process of the pancreas and is potentially reversible. It is characterized by oedema and necrosis of peripancreatic fat and may progress to necrosis of glandular and surrounding tissue. Activation of pancreatic enzymes leads to pancreatic autodigestion and systemic effects.
Satish Keshav, Alexandra Kent
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Journal of the American Medical Association, 1942
The time will soon come when the one who gives the Billings lecture, as well as his audience, will belong to a generation that never knew Frank Billings. Those of us who did have the privilege of his friendship and who are indebted to him for help and leadership delight to honor his memory.
openaire +1 more source
The time will soon come when the one who gives the Billings lecture, as well as his audience, will belong to a generation that never knew Frank Billings. Those of us who did have the privilege of his friendship and who are indebted to him for help and leadership delight to honor his memory.
openaire +1 more source