Results 31 to 40 of about 294,000 (265)

Bibliometric Analysis of Cathepsin B Research From 2011 to 2021

Frontiers in Medicine, 2022
Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number of CTSB-related studies have been conducted to date. However, there is no comprehensive bibliometric analysis on this subject.
Xiaoli Yang, Xiaoli Yang, Hua Yin, Hua Yin, Deyu Zhang, Lisi Peng, Keliang Li, Fang Cui, Chuanchao Xia, Zhaoshen Li, Haojie Huang   +10 more
doaj   +1 more source

Sintilimab-Induced Autoimmune Diabetes in a Patient With the Anti-tumor Effect of Partial Regression

Frontiers in Immunology, 2020
ContextImmune checkpoint blockades (ICBs) have been approved widely to treat various malignancies. Autoimmune diabetes mellitus, which can be caused by programmed cell death protein 1 (PD-1) inhibitors, is rare.
Liang Wen, Liang Wen, Liang Wen, Liang Wen, Xiuwen Zou, Xiuwen Zou, Xiuwen Zou, Yiwen Chen, Yiwen Chen, Yiwen Chen, Yiwen Chen, Xueli Bai, Xueli Bai, Xueli Bai, Xueli Bai, Tingbo Liang, Tingbo Liang, Tingbo Liang, Tingbo Liang   +18 more
doaj   +1 more source

CT Evaluation of Acute Pancreatitis and its Prognostic Correlation with CT Severity Index [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Pancreatitis is one of most complex and clinically challenging of all abdominal disorders. USG and abdominal CT are the most commonly used diagnostic imaging modalities for the evaluation of pancreas.
Sameer Raghuwanshi, Rajesh Gupta, Mahendra Mohan Vyas, Rakesh Sharma   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Evaluation of Intra-Tumoral Vascularization in Hepatocellular Carcinomas

Frontiers in Medicine, 2020
Intratumoral neovascularization has intricate effects on tumor growth, metastasis, and treatment. Over the last 30 years, Microvessel density (MVD) has been the standard method for laboratory and clinical evaluation of angiogenesis.
Qi Zhang, Qi Zhang, Qi Zhang, Qi Zhang, Jiajun Wu, Xueli Bai, Xueli Bai, Xueli Bai, Xueli Bai, Tingbo Liang, Tingbo Liang, Tingbo Liang, Tingbo Liang   +12 more
doaj   +1 more source

Immunity-Related Gene Signature Identifies Subtypes Benefitting From Adjuvant Chemotherapy or Potentially Responding to PD1/PD-L1 Blockage in Pancreatic Cancer

Frontiers in Cell and Developmental Biology, 2021
Tumor microenvironment comprises of a variety of cell types, which is quite complex and involved in chemotherapy and immune checkpoint blockage resistance.
Hao Qian, Hao Qian, Hongzhe Li, Hongzhe Li, Junjie Xie, Junjie Xie, Xiongxiong Lu, Xiongxiong Lu, Fanlu Li, Fanlu Li, Weishen Wang, Weishen Wang, Xiaomei Tang, Xiaomei Tang, Minmin Shi, Minmin Shi, Linxi Jiang, Linxi Jiang, Hongwei Li, Hongwei Li, Hao Chen, Hao Chen, Chenghong Peng, Chenghong Peng, Zhiwei Xu, Zhiwei Xu, Xiaxing Deng, Xiaxing Deng, Baiyong Shen, Baiyong Shen, Baiyong Shen, Baiyong Shen   +31 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Selective occlusion of the hepatic artery and portal vein improves liver hypertrophy for staged hepatectomy

World Journal of Surgical Oncology, 2019
Background To evaluate the safety and feasibility of selective occlusion of the hepatic artery and portal vein (SOAP) for staged hepatectomy (SOAPS) in patients with hepatocellular carcinoma (HCC) Methods From December 2014 to August 2018, 9 patients ...
Changku Jia, Ke Ge, Sunbing Xu, Ling Liu, Jie Weng, Youke Chen   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source