Results 181 to 190 of about 118,689 (360)

Prognostic value of surgical treatment in elderly patients with ulcerative colitis‐associated colorectal cancer: A subanalysis of a nationwide Japanese multicenter study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Our study examined the characteristics of elderly patients diagnosed with ulcerative colitis‐associated colorectal cancer. We showed that factors associated with aggressive tumor characteristics played a significant role in recurrence risk in the nonelderly patients, but not in the elderly patients.
Kinuko Nagayoshi   +10 more
wiley   +1 more source

Nationwide medical database study for postoperative nutritional management in patients undergoing gastroenterological cancer surgery

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
The study aim was to clarify how nutrition was managed in patients based on surgical site during the first 7 d after gastrointestinal cancer surgery. As results, oral intake after gastrointestinal cancer surgery started earliest in patients having liver surgery and latest in patients having esophageal surgery.
Yoshikuni Kawaguchi   +3 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode   +16 more
wiley   +1 more source

Combined effect of frailty and sarcopenia on postoperative complications in older adults undergoing curative surgery for hepato‐biliary‐pancreatic cancer

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
A multivariable logistic regression model was performed using covariates that were significant in the bivariable analyses, including bile duct cancer, longer operative times, and greater blood loss. Prefrail or frail status combined with sarcopenia remained significant in this model (OR 4.74; 95% CI, 1.10–20.29; p = 0.04).
Norifumi Harimoto   +9 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu   +11 more
wiley   +1 more source

Survival benefit of adjuvant therapy completion with early initiation for patients with pancreatic ductal adenocarcinoma

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Adjuvant completion with early initiation may contribute to the improved survival of patients with pancreatic ductal adenocarcinoma. Abstract Aim To evaluate the prognostic effect of initiation timing and completion of adjuvant therapy in patients with pancreatic ductal adenocarcinoma.
Kenjiro Okada   +9 more
wiley   +1 more source

Sites of Pancreatic Duct Obstruction in Chronic Pancreatitis

open access: green, 1959
Alan P. Thal   +2 more
openalex   +2 more sources

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

open access: yesHepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai   +29 more
wiley   +1 more source

Multimodal nonlinear acoustics in two- and three-dimensional curved ducts [PDF]

open access: yesarXiv
We develop a weakly nonlinear model of duct acoustics in two and three dimensions (without flow). The work extends the previous work of McTavish & Brambley (2019, J. Fluid Mech. 875, pp. 411-447) to three dimensions and significantly improves the numerical efficiency.
arxiv  

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