PPAR-alpha: a novel target in pancreatic cancer [PDF]
, 2015 Background: Current targeted therapies in pancreatic cancer have been ineffective. The tumor stroma, including intra- and peri-tumoral inflammation and fibrosis, is increasingly implicated in pancreatic cancer.
Hua, Alexander Mach
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
High expression of tumor‐associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker [PDF]
, 2002 Kei Hiraoka +11 more
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Advanced Science, EarlyView.Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas +16 more
wiley +1 more source
Improving Prognostic Performance in Resectable Pancreatic Ductal Adenocarcinoma using Radiomics and Deep Learning Features Fusion in CT Images [PDF]
arXiv, 2019 As an analytic pipeline for quantitative imaging feature extraction and analysis, radiomics has grown rapidly in the past a few years. Recent studies in radiomics aim to investigate the relationship between tumors imaging features and clinical outcomes.
arxiv
Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models
Surgery Open Science, 2019 Background: Auranofin, a Food and Drug Administration–approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for pancreatic cancer.
Mayrim V. Rios Perez +10 more
doaj
Characterisation of oestrogen receptor, progesterone receptor, trefoil factor 1, and epidermal growth factor and its receptor in pancreatic cystic neoplasms and pancreatic ductal adenocarcinoma [PDF]
, 2002 T-S Yeh
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Annals of Gastroenterological Surgery, EarlyView.Adjuvant completion with early initiation may contribute to the improved survival of patients with pancreatic ductal adenocarcinoma. Abstract Aim To evaluate the prognostic effect of initiation timing and completion of adjuvant therapy in patients with pancreatic ductal adenocarcinoma.
Kenjiro Okada +9 more
wiley +1 more source
Mixed pancreatic acinar cell-ductal adenocarcinoma: Complexities in diagnosis and treatment
Current Problems in Cancer: Case Reports, 2022 Background: Acinar cell carcinoma of the pancreas (ACC) is a rare malignancy, accounting for approximately 1-2% of all pancreatic cancers. Up to a quarter of ACCs are estimated to contain a significant component of another histology such as ...
Abdullah Nasser +4 more
doaj
Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma [PDF]
, 2002 Frédérique Maire
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