Results 201 to 210 of about 64,777 (328)

Hijacking the MDM2 E3 Ligase with novel BRD4‐Targeting PROTACs in Pancreatic Cancer Cells

ChemBioChem, Accepted Article.
The phenotypic effect induced by a Proteolysis‐Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first‐in‐class PROTAC for a target of interest, the E3 ligases commonly hijacked remain the Von Hippel‐Lindau (VHL) and Cereblon (CRBN) since potent and accessible ligands are readily ...
Mihaela Ficu, Dan Niculescu-Duvaz, Mohammed Aljarah, Caroline Springer, Christopher S. Kershaw   +4 more
wiley   +1 more source

Quality of life after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head [PDF]

, 2006
Bodo Schniewind, Beate Bestmann, Doris Henne‐Bruns, Fred Faendrich, B. Kremer, T. Kuechler   +5 more
openalex   +1 more source

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
Small molecules form a covalent bond at KRAS tyrosine and inhibit its activation by guanine exchange factors in biochemical assays and mammalian cells. The development of the KRAS G12C inhibitor sotorasib is a major advance toward drugging KRAS. However, the G12C mutation is only found in about 10% of KRAS‐driven tumors. KRAS possesses several tyrosine
Alexander D. Landgraf, Robert Brenner, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Giovanni Gonzalez‐Gutierrez, Samy O. Meroueh   +5 more
wiley   +1 more source

Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin Mutations

, 2002
Susan C. Abraham, David S. Klimstra, Robb E. Wilentz, Charles J. Yeo, Kevin C. Conlon, Murray F. Brennan, John L. Cameron, Tsung‐Teh Wu, Ralph H. Hruban   +8 more
openalex   +1 more source

A Genetic Twist: Cytologic Evaluation of Pancreatic Adenocarcinoma and Steatohepatitic Hepatocellular Carcinoma in a Patient With a Rare POLE Mutation

Diagnostic Cytopathology, EarlyView.
ABSTRACT Mutations in the DNA polymerase epsilon (POLE) gene are associated with an increased risk of various malignancies, including colorectal and other gastrointestinal, endometrial, ovarian, breast, and brain cancers. In extremely rare cases, POLE mutations have also been associated with pancreatic and hepatobiliary carcinomas.
Lynn Messersmith, Areeba H. Rizvi, Dina El‐Rayes, Jimmie Stewart III   +3 more
wiley   +1 more source

Genetics and biology of pancreatic ductal adenocarcinoma. [PDF]

, 2006
Aram F. Hezel, Alec C. Kimmelman, Ben Z. Stanger, Nabeel Bardeesy, Ronald A. DePinho   +4 more
openalex   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

Exploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan   +4 more
wiley   +1 more source

Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40 [PDF]

, 2006
Frank Bergmann, Sebastian Aulmann, Moritz N. Wente, Roland Penzel, Iréne Esposito, Jörg Kleeff, Helmut Friess, Peter Schirmacher   +7 more
openalex   +1 more source

Surgical and Medical Co‐Management in an 82‐Year‐Old Patient With Hemophilia a Undergoing Pancreaticoduodenectomy

Health Care Science, EarlyView.
The surgical and medical co‐management (SMC) team integrates internists and surgeons to improve perioperative planning to minimize complications and promote recovery. SMCs team implemented various perioperative optimization strategies for the patient to prevent complications and enhance satisfaction.
Wenning Lu, Chaoyang Liu, Jing He, Rui Cheng   +3 more
wiley   +1 more source

Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs [PDF]

, 2007
Ralph H. Hruban, Noriyoshi Fukushima
openalex   +1 more source