Results 191 to 200 of about 433,923 (290)

Clinical Utility of Circulating Tumor DNA Analysis in Pancreatic Ductal Adenocarcinoma. [PDF]

Clin Med Insights Oncol
Lee M, Lee JY, Kang IH, Sung CO, Jun HR, Hwang DW, Jun E, Chun SM.   +7 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma. [PDF]

Cell Oncol (Dordr)
Zhang X, Zhao Y, Qin C, Li Z, Xie Y, Yan Y, Li T, Huang L, Shi H, Wang W.   +9 more
europepmc   +1 more source

Non‐Rigid Motion‐Compensated MR Multitasking for Free‐Breathing Low‐Dose Dynamic Contrast‐Enhanced MRI in the Abdomen

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To improve free‐breathing low‐dose quantitative dynamic contrast‐enhanced (DCE) MRI for imaging pancreatic ductal adenocarcinoma. Methods We introduced non‐rigid (NR) motion compensation (MoCo) into MR Multitasking using a novel “in‐subspace” formulation that directly applies motion fields to spatial feature maps (eigenimages ...
Lingceng Ma, Chaowei Wu, Lixia Wang, Hsu‐Lei Lee, Junzhou Chen, Zheyuan Hu, Yibin Xie, Stephen J. Pandol, Srinivas Gaddam, Debiao Li, Anthony G. Christodoulou   +10 more
wiley   +1 more source

Targeted Therapy in Pancreatic Ductal Adenocarcinoma: Current Advances and Challenges. [PDF]

Curr Oncol
Habib R, Arnold E, Obi T, Vizeacoumar FJ, Ahmed S.   +4 more
europepmc   +1 more source

Pancreatic ductal adenocarcinoma

, 2009
Frank Gaillard, Mohammad Taghi Niknejad, Abdus Sattar   +2 more
openaire   +1 more source

CAFs‐mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression

The Journal of Pathology, EarlyView.
Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li, Jun Hu, Lei Huang, Zihao Wang, Haoran Tao, Feng Cao, Min Xie   +6 more
wiley   +1 more source

Pancreatic ductal adenocarcinoma and edema: reassessing cachexia markers. [PDF]

J Gastrointest Oncol
Muqbil I, Stevens C, Saif MW.
europepmc   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source