Results 191 to 200 of about 84,228 (303)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Diabetes-Driven Post-Translational Remodeling in Pancreatic Ductal Adenocarcinoma. [PDF]

Cancers (Basel)
Kavyashree S, Harithpriya K, Ganesan K, Ramkumar KM.   +3 more
europepmc   +1 more source

Head and Neck Metastases From Infraclavicular Primary Tumors: Analysis of 136 Cases

The Laryngoscope, EarlyView.
ABSTRACT Objective Distant metastases in the head and neck region are rare, often posing challenges for ENT specialists and being of crucial importance in the management of infraclavicular primary tumors. Methods The case series presented here aims to outline the relevant aetiologies and clinical presentation in the head and neck region.
Achim M. Franzen, André Buchali, Carolin Quadt, Annekatrin Coordes   +3 more
wiley   +1 more source

Global profiling of protein lactylation in pancreatic ductal adenocarcinoma. [PDF]

Sci Rep
Toledo D, Oluwole SA, Owiredu S, Carr G, Agatemor C.   +4 more
europepmc   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

TLR2 signaling regulates T cell exclusion in pancreatic ductal adenocarcinoma. [PDF]

JCI Insight
Plesset J, Stone ML, McVey JC, Coho H, Markowitz K, Coho K, Lee J, Thickens AS, Delman D, Beatty GL.   +9 more
europepmc   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Clinical and prognostic implications of KRT19 expression in pancreatic ductal adenocarcinoma. [PDF]

Transl Cancer Res
An HJ, Cho KB, Shin KI.
europepmc   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Pancreatic Steatosis as a Risk Phenotype for Pancreatic Ductal Adenocarcinoma: A Narrative Review. [PDF]

Medicina (Kaunas)
Cammarata R, La Vaccara V, Bani L, Giordano F, Castagliuolo P, Ristori MV, Aita SE, Angeletti S, Coppola R, Caputo D.   +9 more
europepmc   +1 more source