Results 271 to 280 of about 217,476 (395)

BTG1 low expression in pancreatic ductal adenocarcinoma is associated with a poorer prognosis [PDF]

, 2017
Yu-Fang Huang, Jiawei Zheng, Ting Tan, Li Song, Shanshan Huang, Yan Zhang, Lin Lin, Jingnan Liu, Peichan Zheng, Xiong Chen, Xi Chen, Xuenong Ouyang   +11 more
openalex   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Understanding the heterogeneity of pancreatic ductal adenocarcinoma. [PDF]

Transl Oncol
Iovanna J, Fraunhoffer N, Urrutia R, Dusetti N.   +3 more
europepmc   +1 more source

Nomogram for predicting post-progression-free survival in patients with recurrent pancreatic ductal adenocarcinoma after radical surgery: a retrospective analysis

Dailei Qin, Pu Xi, Kewei Huang, Lingmin Jiang, Zehui Yao, Ran Wei, Shengping Li   +6 more
openalex   +1 more source

Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug [PDF]

Shun Kishimoto, Daniel R. Crooks, Yasunori Otowa, Yamashita Kota, Kazutoshi Yamamoto, W. Marston Linehan, Mark N. Levine, Murali C. Krishna, Jeffrey Brender   +8 more
openalex   +1 more source

Peer Review #3 of "Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis (v0.1)"

, 2020
Jingyi Ding, Yanxi Liu, Yu Lai
openalex   +1 more source

Enhanced Radionuclide Therapy via the Conjugation of Pentadecanoic Acids With 225Ac‐ and 177Lu‐Labeled RGD Peptides

Cancer Science, EarlyView.
Radionuclide therapy using PD‐K(225Ac‐DOTA)‐RGD in BxPC‐3‐bearing mice. PD‐K(225Ac‐DOTA)‐RGD successfully suppressed tumor growth. ABSTRACT Improved peptide pharmacokinetics are needed to enhance the therapeutic effects of peptide‐based radionuclide therapy.
Mitsuyoshi Yoshimoto, Shun‐ichi Wada, Yukie Yoshii, Sayaka Hanadate, Anri Inaki, Hirofumi Fujii   +5 more
wiley   +1 more source

A Combinatorial Effect of Immune Checkpoint Inhibitors and CD40 Agonistic Antibody in Murine Pancreatic Cancer Model

Cancer Science, EarlyView.
We established and extensively analyzed an organoid‐based mouse model that closely mimics human pancreatic ductal adenocarcinoma. Monotherapy with an immune checkpoint inhibitor cocktail or a CD40 agonist antibody showed minimal efficacy. However, combining both reagents produced a strong synergistic effect by enhancing anti‐tumor immunity.
Juri Ichikawa, Hiroshi Okuda, Kuniyuki Kawano, Shingo Kato, Shinya Sato, Ryo Kuroishikawa, Daisuke Kurotaki, Wataru Kawase, Haruka Yoshida, Yukihiko Hiroshima, Itaru Endo, Shin Maeda, Tomohiko Tamura   +12 more
wiley   +1 more source

Incorporating a new criteria of resectability for pancreatic ductal adenocarcinoma [PDF]

Marcos Belotto, Luís Felipe Leite, Renata D’Alpino Peixoto, Eduardo de Souza Martins Fernandes, Orlando Jorge Martins Torres   +4 more
openalex   +1 more source

Spatial Location of SPP1+TAMs and Mutually Exclusive Subsets Based on Single‐Cell and Transcriptome Data

Cancer Science, EarlyView.
This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo, JianGuo Xu, ZhiYuan Wang, XiaoFang Wang, YangHao Wang, Yu Zhang, FangFang Li, Hui Fang, XiaoYun Huang, MuYe Li, XiaoJuan Liu, JiHong Tang, PeiYang Fan, GuoJing Zhao, YongWen He, Li Bian   +15 more
wiley   +1 more source