Results 271 to 280 of about 64,777 (328)
Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma
, 2010 Raghunandan Vikram, Aparna Balachandran
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In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks
Cancer Science, EarlyView.In this review, the authors first introduce genetic aberrations that cause cancer development. Then, they illustrate the impact of epigenetic abnormalities in cancer, especially with reference to studies that use in vivo reprogramming technologies. Finally, the authors discuss the importance of histological evaluations of tumor tissue to understand non‐
Yosuke Yamada +2 more
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Cancer Science, EarlyView.This study analyzed 1356 cases using GenMineTOP, Japan's first dual DNA–RNA CGP test, and identified oncogenic alterations in 91.5% of cases. The RNA panel detected 105 fusion events, including 11 NTRK fusions. Furthermore, the analysis clarified the independent effects of genomic abnormalities and cancer type on RNA expression, providing valuable ...
Kousuke Watanabe +7 more
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Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges
Cancer Science, EarlyView.Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li +3 more
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Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression
Cancer Science, EarlyView.In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu +6 more
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Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects
Cell Proliferation, EarlyView.The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang +3 more
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IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target
Cell Proliferation, EarlyView.IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li +8 more
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