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Pancreatic and islet transplantation
Current Gastroenterology Reports, 2000Diabetes mellitus is the most devastating chronic disease of all time. This review discusses the current therapies for type 1 diabetes that are predicated on the restoration of insulin secretion by transplantation. Recent developments in vascularized pancreas transplantation have led to a dramatic increase in the number of these procedures performed ...
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Pflügers Archiv, 2000
Pancreatic islets are neuroendocrine organs that control blood glucose homeostasis. The precise interplay of a heterogeneous group of cell populations (beta, alpha, delta and PP cells) results in the fine-tuned release of counterbalanced hormones (insulin, glucagon, somatostatin and pancreatic polypeptide respectively).
B, Soria +13 more
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Pancreatic islets are neuroendocrine organs that control blood glucose homeostasis. The precise interplay of a heterogeneous group of cell populations (beta, alpha, delta and PP cells) results in the fine-tuned release of counterbalanced hormones (insulin, glucagon, somatostatin and pancreatic polypeptide respectively).
B, Soria +13 more
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La Presse Médicale, 2012
Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies on the detection of insulitis, of islet cell antibodies, of activated β-cell-specific T lymphocytes and on the association of T1D with a restricted set of class II major ...
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Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies on the detection of insulitis, of islet cell antibodies, of activated β-cell-specific T lymphocytes and on the association of T1D with a restricted set of class II major ...
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Lactate Production in Pancreatic Islets
Diabetes, 1998Lactate production, glucose utilization, glucose oxidation, and insulin release were studied in islets from rat and ob/ob mice. Lactate was determined with a highly sensitive method, based on esterification, subsequent separation, and quantitation with high-performance liquid chromatography.
J, Tamarit-Rodriguez +4 more
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1999
Publisher Summary Appropriately, research with emphasis on the endocrine pancreas has grown; in fact, a virtual explosion of discoveries, regarding pancreas development, has occurred over the past few years. The goal in this field is to identify the molecular events that govern pancreas functionality and the genetic components that delineate these ...
D E, Bramblett, H P, Huang, M J, Tsai
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Publisher Summary Appropriately, research with emphasis on the endocrine pancreas has grown; in fact, a virtual explosion of discoveries, regarding pancreas development, has occurred over the past few years. The goal in this field is to identify the molecular events that govern pancreas functionality and the genetic components that delineate these ...
D E, Bramblett, H P, Huang, M J, Tsai
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Resistin is expressed in pancreatic islets
Biochemical and Biophysical Research Communications, 2003Resistin, a recently described adipocyte factor, is regulated by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. While resistin has been proposed to mediate insulin resistance in rodents, little is known about human resistin and its expression in pancreatic islets has not been tested.
Alexandra H, Minn +7 more
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Transglutaminase activity in pancreatic islets
Biochimica et Biophysica Acta (BBA) - General Subjects, 19831. Pancreatic islet homogenates catalyze, in a Ca2+-dependent fashion, the incorporation of [2,5-3H]histamine, [1,4-14C]putrescine, [1,2-3H]agmatine, [14C]methylamine and L-[U-14C]lysine in N,N-dimethylcasein. 2. Using [2,5-3H]histamine as the amine donor, the Km for Ca2+ and histamine amounts to 90 microM and 0.7 mM, respectively. 3. The incorporation
Gomis, Ramon +3 more
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Unravelling innervation of pancreatic islets
Diabetologia, 2022The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, investigated the contribution of sympathetic, parasympathetic and sensory ...
Rollie F. Hampton +2 more
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Statistical geometry of pancreatic islets
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1992Quantitative histomorphometric studies of the dynamics of growth and development of pancreatic islets in normal and pathological states pose substantial methodological and conceptual problems. We address these problems with the geometry of random fractals, and apply our methods to the analysis of islet regeneration in the alloxan-treated guinea-pig. In
H M, Hastings +5 more
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Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets
Diabetes, 1993This study investigated the effect of glucose on islet amyloid polypeptide secretion, content, and mRNA synthesis of human pancreatic islets. The release of islet amyloid polypeptide from fresh isolated islets in response to glucose was parallel to that of insulin.
A, Novials +4 more
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