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Wnt Signaling in Pancreatic Islets
2010The Wnt signaling pathway is critically important not only for stem cell amplification, differentiation, and migration, but also is important for organogenesis and the development of the body plan. Beta-catenin/TCF7L2-dependent Wnt signaling (the canonical pathway) is involved in pancreas development, islet function, and insulin production and ...
Zhengyu, Liu, Joel F, Habener
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PRESERVATION AND STORAGE OF PANCREATIC ISLETS
Transplantation, 1994UW solution is currently the best available for short-term cold storage of pancreatic islets for up to 3-5 days, culture for up to 10-14 days, and cryopreservation for longer periods. More research needs to be done to find a better solution, specifically for cold storage of islets.
R M, Jindal, R, Jindal, D, Gray
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Optogenetic Control of Pancreatic Islets
2016In light of the emerging diabetes epidemic, new experimental approaches in islet research are needed to elucidate the mechanisms behind pancreatic islet dysfunction and to facilitate the development of more effective therapies. Optogenetics has created numerous new experimental tools enabling us to gain insights into processes little was known about ...
Thomas M, Reinbothe, Inês G, Mollet
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Localization of Endocrine Pancreatic Islets
World Journal of Surgery, 1996AbstractTransplantation of whole pancreas or pancreatic islets remains a promising approach to treatment of diabetes mellitus. Because at present there is no efficient method for in vivo early diagnosis of pancreatic islet rejection or for disorders of pancreatic endocrine function, we examined if dithizone (DTZ) and a synthetic iodo‐derivative of DTZ (
P S, Fiedor, S F, Oluwole, M A, Hardy
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Biosynthesis of pancreatic islet hormones
Hepatology, 1987We have outlined the various strategies used to characterize the precursors of three pancreatic islet hormones--somatostatin, pancreatic polypeptide and VIP. In each case, isolation of the cDNA clones was facilitated by the use of gastrointestinal tissues that were extremely rich in specific mRNA. Characterization of the structures of the precursors is
R H, Goodman +6 more
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Protein profiling of pancreatic islets
Expert Review of Proteomics, 2006The insulin-producing beta cell in the islet of Langerhans is central in glucose homeostasis. Its dysfunction is part of the pathogenesis of both Type 1 and 2 diabetes mellitus. In both forms of the disease, there is a cytotoxic component either induced by cytokines, as in Type 1 diabetes, or by elevated levels of glucose and fatty acids, as in Type 2 ...
Henrik, Ortsäter, Peter, Bergsten
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THE ISLETS OF LANGERHANS IN PANCREATIC FIBROSIS
Pediatrics, 1958A survey is given of earlier views on the occurrence of diabetes and decreased glucose tolerance in cystic fibrosis of the pancreas, as well as on the structure of the islet tissue in this disease and in experimental fibrosis of the pancreas. Intravenous glucose tolerance tests were performed in three patients with cystic fibrosis.
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Epigenetic Regulation of Pancreatic Islets
Current Diabetes Reports, 2013Epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding RNA expression, contribute to regulate islet cell development and function. Indeed, epigenetic mechanisms were recently shown to be involved in the control of endocrine cell fate decision, islet differentiation, β-cell identity, proliferation, and mature function ...
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Cyborg pancreatic islet organoids
ScienceBio-nanoelectronic islets are new tools for diabetes research and ...
Jochen, Lang, Matthieu, Raoux
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Observations on the Innervation of the Pancreatic Islets
Archives of Surgery, 1960This study was prompted by the current interest in the so-called ulcerogenic tumors of the pancreas. 1 Reported cases have led to the speculation that a hormone-like mechanism may arise in, or be closely related to, the non-β cells of the islets of Langerhans. A possibility that neural mechanisms, or neuroendocrine mechanisms, might be involved, seemed
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