Results 1 to 10 of about 72,995 (257)

QSAR model of pancreatic lipase inhibition by phenolic acids and their derivatives based on machine learning and multi-descriptor strategy

open access: goldJournal of Agriculture and Food Research, 2023
Inhibition of pancreatic lipase can be effective in controlling or treating obesity. Phenolic acids have good pancreatic lipase inhibitory effects and are widely found in plants.
Yaqi Liu   +8 more
doaj   +2 more sources

Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies [PDF]

open access: hybridJournal of Lipid Research, 2005
Interference with fat hydrolysis results in the reduced use of ingested lipids. Inhibition of pancreatic lipase reduces the efficiency of fat absorption in the small intestine and thereby initiates modest long-term reduction in body weight. In an attempt
M. Lunder   +3 more
doaj   +2 more sources

Combining kinetics and in silico approaches to evaluate bromhexine as an anti-pancreatic lipase agent for obesity management [PDF]

open access: yesScientific Reports
Industrialization, fast food intake and reduced physical activity, mainly in developed countries, exacerbate obesity and make it a major lifestyle disorder. A promising strategy for developing effective anti-obesity agents is to inhibit pancreatic lipase,
Asma Gholami   +2 more
doaj   +2 more sources

Lignocellulosic Waste Compounds for Pancreatic Lipase Inhibition: Preliminary Extraction by Freon, Obtaining of Proanthocyanidins and Testing on Lipase Activity [PDF]

open access: yesMetabolites, 2023
The twigs of sea buckthorn, blackcurrant, gooseberries, quince, and grapes were evaluated as a promising source of biologically active compounds—proanthocyanidins (PACs).
Anna Andersone   +7 more
doaj   +2 more sources

Inhibitory Activity of Pancreatic Lipase by Wungu (Graptophyllum pictum (L.) Griff.) Leaf Extract [PDF]

open access: diamondBIO Web of Conferences
Obesity is a problem in many parts of the world, and its prevalence is increasing rapidly. Inhibition of pancreatic lipase to inhibit triglyceride hydrolysis can prevent obesity and reduce its prevalence, so drugs that can inhibit pancreatic lipase are ...
Khairani Nurul   +3 more
doaj   +2 more sources

Porcine Pancreatic Lipase

open access: hybridJournal of Biological Chemistry, 1972
Charles W. Garner, Louis C. Smith
openalex   +2 more sources

Screening of Anti-Lipase Components of Artemisia argyi Leaves Based on Spectrum-Effect Relationships and HPLC-MS/MS

open access: yesFrontiers in Pharmacology, 2021
Pancreatic lipase is a key lipase for triacylglyceride digestion and absorption, which is recognized as a promising target for treatment of metabolic disorders. Natural phytochemicals are hopeful sources for pancreatic lipase inhibitors.
Yaqing Chang   +5 more
doaj   +1 more source

Novel angiotensin-converting enzyme and pancreatic lipase oligopeptide inhibitors from fermented rice bran

open access: yesFrontiers in Nutrition, 2022
This study determined the inhibitory activity of oligopeptides against angiotensin-converting enzyme (ACE) and pancreatic lipase through in vitro tests, molecular docking, and enzyme inhibition.
Jingfei Hu   +23 more
doaj   +1 more source

Free Linoleic Acid and Oleic Acid Reduce Fat Digestion and Absorption In Vivo as Potent Pancreatic Lipase Inhibitors Derived from Sesame Meal

open access: yesMolecules, 2022
Pancreatic lipase catalyzes the cleavage of triacylglycerols at the oil–water interface, and is known as the dominant determiner of dietary fat digestion.
Xuan Li   +7 more
doaj   +1 more source

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