Results 1 to 10 of about 69,654 (285)

Combining kinetics and in silico approaches to evaluate bromhexine as an anti-pancreatic lipase agent for obesity management [PDF]

Scientific Reports
Industrialization, fast food intake and reduced physical activity, mainly in developed countries, exacerbate obesity and make it a major lifestyle disorder. A promising strategy for developing effective anti-obesity agents is to inhibit pancreatic lipase,
Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson   +2 more
doaj   +2 more sources

Lignocellulosic Waste Compounds for Pancreatic Lipase Inhibition: Preliminary Extraction by Freon, Obtaining of Proanthocyanidins and Testing on Lipase Activity [PDF]

Metabolites, 2023
The twigs of sea buckthorn, blackcurrant, gooseberries, quince, and grapes were evaluated as a promising source of biologically active compounds—proanthocyanidins (PACs).
Anna Andersone, Sarmite Janceva, Liga Lauberte, Jelena Krasilnikova, Natalija Zaharova, Vizma Nikolajeva, Gints Rieksts, Galina Telysheva   +7 more
doaj   +2 more sources

QSAR model of pancreatic lipase inhibition by phenolic acids and their derivatives based on machine learning and multi-descriptor strategy

Journal of Agriculture and Food Research, 2023
Inhibition of pancreatic lipase can be effective in controlling or treating obesity. Phenolic acids have good pancreatic lipase inhibitory effects and are widely found in plants.
Yaqi Liu, Fei Pan, Ou Wang, Zehui Zhu, Qing Li, Zicheng Yang, Wenli Tian, Liang Zhao, Lei Zhao   +8 more
doaj   +1 more source

Screening of Anti-Lipase Components of Artemisia argyi Leaves Based on Spectrum-Effect Relationships and HPLC-MS/MS

Frontiers in Pharmacology, 2021
Pancreatic lipase is a key lipase for triacylglyceride digestion and absorption, which is recognized as a promising target for treatment of metabolic disorders. Natural phytochemicals are hopeful sources for pancreatic lipase inhibitors.
Yaqing Chang, Dan Zhang, Guiya Yang, Yuguang Zheng, Yuguang Zheng, Long Guo   +5 more
doaj   +1 more source

Novel angiotensin-converting enzyme and pancreatic lipase oligopeptide inhibitors from fermented rice bran

Frontiers in Nutrition, 2022
This study determined the inhibitory activity of oligopeptides against angiotensin-converting enzyme (ACE) and pancreatic lipase through in vitro tests, molecular docking, and enzyme inhibition.
Jingfei Hu, Jingfei Hu, Jingfei Hu, Huanyu Wang, Huanyu Wang, Huanyu Wang, Nanhai Weng, Nanhai Weng, Nanhai Weng, Tong Wei, Tong Wei, Tong Wei, Xueqing Tian, Xueqing Tian, Xueqing Tian, Jing Lu, Jing Lu, Jing Lu, Mingsheng Lyu, Mingsheng Lyu, Mingsheng Lyu, Shujun Wang, Shujun Wang, Shujun Wang   +23 more
doaj   +1 more source

Free Linoleic Acid and Oleic Acid Reduce Fat Digestion and Absorption In Vivo as Potent Pancreatic Lipase Inhibitors Derived from Sesame Meal

Molecules, 2022
Pancreatic lipase catalyzes the cleavage of triacylglycerols at the oil–water interface, and is known as the dominant determiner of dietary fat digestion.
Xuan Li, Sayo Morita, Hiroaki Yamada, Keita Koga, Wakana Ota, Toma Furuta, Atsushi Yamatsu, Mujo Kim   +7 more
doaj   +1 more source

Study on the Interaction Process between Rape Bee Pollen Polyphenols and Pancreatic Lipase by Ultraviolet andFluorescence Spectroscopy

Shipin gongye ke-ji, 2023
In this study, the inhibitory effect of rape bee pollen polyphenols on pancreatic lipase was measured by enzyme kinetics method, and the interaction between pancreatic lipase and rape bee pollen polyphenol extracts was analyzed by the ultravilolet ...
Nan ZHANG, Tongxia HU, Xinli ZHU, Xuemei YANG, Lei WANG, Fan WU, Hongliang LI   +6 more
doaj   +1 more source

Protective effect of chitosan against growth inhibition and pancreatic oxidative stress in weaned piglets

Journal of Applied Animal Research, 2022
This study was undertaken to determine the protective effect of chitosan against oxidative injury in pancreas of weaned piglets. A 2 × 2 factorial experiment was conducted.
Yuanqing Xu, Zheqi Wang, Sumei Yan, Binlin Shi   +3 more
doaj   +1 more source

Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States

Frontiers in Genetics, 2021
Pancreatic lipase is critical for the digestion and absorption of dietary fats. The most abundant lipolytic enzymes secreted by the pancreas are pancreatic triglyceride lipase (PTL or PNLIP) and its family members, pancreatic lipase-related protein 1 ...
Guoying Zhu, Guoying Zhu, Qing Fang, Fengshang Zhu, Dongping Huang, Changqing Yang   +5 more
doaj   +1 more source

Senyawa Fucodiphlorethol Dan Phloroglucinol Alga Coklat Sebagai Inhibitor Lipase Secara In Silico

Florea: Jurnal Biologi dan Pembelajarannya, 2022
Brown algae is a marine functional food that high fibers, vitamins, and bioactive compounds. Brown algae improved blood glucose and lipid profile. This study investigated the potential activity of two bioactive compounds from brown algae, as anti-obesity
Yohanes Bare, Dewi Ratih Tirto Sari, Marsiana Coo Mogi, Maria Marcelina Dua Nurak   +3 more
doaj   +1 more source