Results 71 to 80 of about 70,654 (358)

Inhibition of lipases by ∊-polylysine

Journal of Lipid Research, 2003
Oral administration of ∊-polylysine to rats reduced the peak plasma triacylglycerol concentration. In vitro, ∊-polylysine and polylysine strongly inhibited the hydrolysis, by either pancreatic lipase or carboxylester lipase, of trioleoylglycerol (TO ...
Takahiro Tsujita, Maho Sumiyoshi, Takeshi Takaku, William E. Momsen, Mark E. Lowe, Howard L. Brockman   +5 more
doaj   +1 more source

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Curcumin nano-formulation with enhanced pancreatic lipase inhibition

MGM Journal of Medical Sciences
Background: Curcumin has been recognized for its diverse therapeutic effects. Little is known about the impact of curcumin on pancreatic lipase inhibition. In recent years, researchers have explored curcumin with new and improved properties.
Harshita Mohanty, Raman P. Yadav
doaj   +1 more source

Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies

Journal of Lipid Research, 2005
Interference with fat hydrolysis results in the reduced use of ingested lipids. Inhibition of pancreatic lipase reduces the efficiency of fat absorption in the small intestine and thereby initiates modest long-term reduction in body weight. In an attempt
M. Lunder, T. Bratkovič, S. Kreft, B. Štrukelj   +3 more
doaj   +1 more source

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage

Advanced Science, EarlyView.
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu, Fei Han, Yaodong Wang, Chenchen Yuan, Qingtian Zhu, Tianqi Xia, Lin Chen, Xiaowu Dong, Yanbing Ding, Weiming Xiao, Yuyan Zhang, Jiajia Pan, Hongwei Xu, Weiwei Chen, Bo Tu, Wei Li, Fei Wang, Weijuan Gong, Lianghao Hu   +18 more
wiley   +1 more source

Structural basis of the chiral selectivity of Pseudomonas cepacia lipase [PDF]

, 1998
To investigate the enantioselectivity of Pseudomonas cepacia lipase, inhibition studies were performed with SC- and RC-(RP,SP)-1,2-dialkylcarbamoylglycero-3-O-p-nitrophenyl alkylphosphonates of different alkyl chain lengths. P.
Dijkstra, Bauke W.,, Haas, Gerard H. de,, Lang, Dietmar A.,, Mannesse, Maurice L.M.,, Verheij, Hubertus M.,   +4 more
core   +2 more sources

Dietary Fat Patterns and Outcomes in Acute Pancreatitis in Spain [PDF]

, 2020
Background/Objective: Evidence from basic and clinical studies suggests that unsaturated fatty acids (UFAs) might be relevant mediators of the development of complications in acute pancreatitis (AP).
Argüelles-Arias, A.M., Balza-Lareu, N., Bertoletti, Federico, Bodenlle-Bello, M.P., Cervera, J.I., Closa, D., de-Madaria, E., Ferrández, Á., García-Figueiras, R., García-Rayado, G., Gil-García-Ollauri, C., Guzmán-Suárez, S., Ituarte-Uriarte, R., Lanas, Á., Lariño-Noia, J., Latorre, P., Menso, Maria, Mesa-Álvarez, A., Oblitas, Elida, Rodríguez-Peláez, M., Rodríguez-Prada, J.I., Rosales-Alexander, C.L., Soria-de-la-Cruz, M.J., Soriano, J., Udaondo-Cascante, M.A., Universitat Autònoma de Barcelona, Varela-Moreiras, G.   +26 more
core   +4 more sources

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science, EarlyView.
A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo, Huang Yang, Xiaoming Jiang, Zheng Wang, Xuxiao He, Ying Meng, Shan Li, Min Li, Daqian Xu, Zhengwei Mao, Zhimin Lu   +10 more
wiley   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis

Zanco Journal of Medical Sciences, 2020
Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas.
Ahmed Abdulkadir Baban
doaj   +1 more source