Results 91 to 100 of about 152,984 (289)

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

A Long Non-coding RNA Signature to Improve Prognostic Prediction of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2019
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid malignant tumors worldwide. Increasing investigations demonstrate that long non-coding RNAs (lncRNAs) expression is abnormally dysregulated in cancers.
Chenhao Zhou, Shun Wang, Qiang Zhou, Jin Zhao, Xianghou Xia, Wanyong Chen, Wanyong Chen, Yan Zheng, Min Xue, Feng Yang, Deliang Fu, Yirui Yin, Manar Atyah, Lunxiu Qin, Lunxiu Qin, Yue Zhao, Christiane Bruns, Huliang Jia, Ning Ren, Ning Ren, Qiongzhu Dong, Qiongzhu Dong   +21 more
doaj   +1 more source

Commissioning of Halcyon enhanced leaf model in the Eclipse treatment planning system: Focus on simple slit fields and VMAT dose calculation

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The dual‐layer multileaf collimator (MLC) in Halcyon adds complexities to the dose calculation process owing to the variability of dosimetric characteristics with leaf motion. Recently, an enhanced leaf model (ELM) was developed to refine the MLC model in the Eclipse treatment planning system. This study investigates the performance of
Ryohei Miyasaka, Mari Shirai, Mitsunobu Igari, Yume Kojima, Yuki Kozawa, Toru Kawachi, Ryusuke Hara   +6 more
wiley   +1 more source

Inhibition of Liver Metastasis of Human Pancreatic Carcinoma by Angiogenesis Inhibitor TNP‐470 in Combination with Cisplatin [PDF]

, 1998
Takayuki Shishido, Takahiro Yasoshima, Ryuichi Denno, Mitsuhiro Mukaiya, Noriyuki Sato, Koichi Hirata   +5 more
openalex   +1 more source

Impact of bulk density assignment of bone on MRI‐based abdominal region radiotherapy planning for MR‐linac workflow

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The purpose of the present study was to evaluate the impact of bone relative electron density (rED) assignment on radiotherapy planning for the abdominal region. Methods Twenty patients who received abdominal radiotherapy using MR‐Linac and underwent magnetic resonance imaging (MRI) and computed tomography (CT) simulation were analyzed.
Kota Abe, Masato Tsuneda, Yukio Fujita, Yukinao Abe, Takashi Uno   +4 more
wiley   +1 more source

Novel CT radiomics models for the postoperative prediction of early recurrence of resectable pancreatic adenocarcinoma: A single‐center retrospective study in China

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To assess the predictive capability of CT radiomics features for early recurrence (ER) of pancreatic ductal adenocarcinoma (PDAC). Methods Postoperative PDAC patients were retrospectively selected, all of whom had undergone preoperative CT imaging and surgery. Both patients with resectable or borderline‐resectable pancreatic cancer met
Xinze Du, Yongsu Ma, Kexin Wang, Xiejian Zhong, Jianxin Wang, Xiaodong Tian, Xiaoying Wang, Yinmo Yang   +7 more
wiley   +1 more source

Effect of Angiostatin on Liver Metastasis of Pancreatic Cancer in Hamsters [PDF]

, 2000
Ken Yanagi, Masahiko Onda, Eiji Uchida
openalex   +1 more source

Enhanced analysis of gating latency in 0.35T MR‐linac through innovative time synchronization of a motion phantom and plastic scintillation detector

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to evaluate how different gantry angles, breathing rates (BPM), cine image speeds, and tracking algorithms affect beam on/off latency and the subsequent impact on target dose for a 0.35T MR‐Linac with a 6 MV FFF beam.
Mateb Al Khalifa, Tianjun Ma, Haya Aljuaid, Siyong Kim, William Y. Song   +4 more
wiley   +1 more source