Results 151 to 160 of about 273,218 (326)

A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma [PDF]

, 2022
Chunle Zhao, Jun Gong, Yu Bai, Taoyuan Yin, Min Zhou, Shutao Pan, Yuhui Liu, Yang Gao, Zhenxiong Zhang, Yongkang Shi, Feng Zhu, Hang Zhang, Min Wang, Renyi Qin   +13 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Pancreatic Ductal Adenocarcinoma: MicroRNAs Affecting Tumor Growth and Metastasis in Preclinical In Vivo Models [PDF]

, 2019
Ulrich H. Weidle, Fabian Birzele, Adam Nopora   +2 more
openalex   +1 more source

Ovarian Metastasis from Pancreatic Ductal Carcinoma

Revista Española de Enfermedades Digestivas
A clinical case is presented about a rare presentation of pancreatic cancer. Firstly, pancreatic cancer rarely metastasizes to the ovary, and when it does, it usually presents in the form of peritoneal carcinomatosis and bilateral involvement. However, the initial radiological diagnosis was primary pancreatic carcinoma with a synchronous primary ...
Cobarro JE, Ramia Ángel JM, Carbonell Morote S, Marcos Sanmartín J, Alcázar-López CF, Villodre Tudela C, Melgar Requena P, García Vega C   +7 more
openaire   +3 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Supplementary Materials and Methods from Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer

, 2023
Agnieszka A. Rucki, Kelly Foley, Pingbo Zhang, Qian Xiao, Jennifer Kleponis, Annie A. Wu, Rajni Sharma, Guanglan Mo, Angen Liu, Jennifer E. Van Eyk, Elizabeth M. Jaffee, Lei Zheng   +11 more
openalex   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Supplementary Data from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

, 2023
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxán‐Delgado, Óscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J.G. Drake, Jesús Gómez-Escudero, Frances M. Richards, Céline Weller, Christof Dormann, Ya-Ming Meng, Peter Vermeulen, Dieter Saur, Victoria Sanz‐Moreno, Ping‐Pui Wong, Cyrill Géraud, Pedro R. Cutillas, Kairbaan Hodivala‐Dilke   +19 more
openalex   +1 more source

LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer [PDF]

, 2021
Jian Xu, Jie Wang, Zhiwei He, Peng Chen, Xueyi Jiang, Yankun Chen, Xinyuan Liu, Jianxin Jiang   +7 more
openalex   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source