Results 231 to 240 of about 240,816 (350)

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer [PDF]

, 2009
Jennifer P. Morton, Paul Timpson, Saadia A. Karim, Rachel A. Ridgway, Dimitris Athineos, Brendan Doyle, Nigel B. Jamieson, Karin A. Oien, Andrew M. Lowy, Valerie G. Brunton, Margaret C. Frame, T.R. Jeffry Evans, Owen J. Sansom   +12 more
openalex   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Case Report: ¹⁸F-FDG PET/CT revealed diffuse pancreatic metastasis in paranasal sinuses rhabdomyosarcoma after treatment improvement. [PDF]

Front Med (Lausanne)
Hu X, Duan H, Zhao Y, Wang Y, Pan D.
europepmc   +1 more source

β-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis

, 2005
Yujun Li
openalex   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Isolated Pancreatic Metastasis in a Patient With Orbital Rhabdomyosarcoma: A Report of a Rare Case. [PDF]

Cureus
Idrees RB, Malik M, Mustanser A, Sarwar T, Kousar F, Chaudhary MH.   +5 more
europepmc   +1 more source

Merkel Cell Carcinoma With Isolated Pancreatic Metastasis. [PDF]

J Investig Med High Impact Case Rep, 2021
Lingamaneni P, Laswi H, Krbanjevic A, Moturi K, Katiyar V, Gupta S.   +5 more
europepmc   +1 more source

A Case of Pancreatic Cancer with Liver Metastasis Presenting Problematic Preoperative Diagnosis

, 2005
Tatsuma Imura, Naoya Ikeda, Masayuki Sho, Ryo Nishinuma, Junko NOMURA, Michihiro Narikiyo, Yoshiyuki Nakajima   +6 more
openalex   +2 more sources

A Novel Role of Interleukin-13 Receptor α2 in Pancreatic Cancer Invasion and Metastasis [PDF]

, 2009
Toshio Fujisawa, Bharat Joshi, Atsushi Nakajima, Raj K. Puri   +3 more
openalex   +1 more source

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source