Results 111 to 120 of about 576,341 (292)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Diabetic ketoacidosis as the presenting manifestation of pancreatic adenocarcinoma with cystic features

Turkish Journal of Emergency Medicine, 2017
The common presenting symptoms of pancreatic cancer are abdominal pain, weight loss, and jaundice. Pancreatic adenocarcinoma presenting with diabetic ketoacidosis is a very rare emergent clinical condition.
Tezcan Kaya, Sumeyye Korkmaz, Erdem Vargol, Alper Karacan, Hakan Cinemre   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

An appraisal of pancreatic cyst fluid molecular markers

Gastrointestinal Intervention, 2017
Pancreatic malignancy is the third leading cause of cancer related death in the United States with limited viable screening options. By the end of this decade, cancers are poised to become the leading cause of death with pancreatic cancer projected to be
Rohan M. Modi, Ravi B. Pavurala, Somashekar G. Krishna   +2 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Pathology and molecular biology of intraductal papillary mucinous neoplasms

, 2008
In recent times, the reported incidence of intraductal papillary mucinous neoplasms (IPMN) has increased dramatically. There is no clear reason for this striking increase with some arguing that awareness and recognition of IPMN, improved imaging ...
Merrett, Neil D. (R14270), Neil D. Merrett, Andrew V. Biankin, James G. Kench, Kench, James G., Cosman, Peter H., Peter H. Cosman, Biankin, Andrew V.   +7 more
core   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Recent developments in endoscopic ultrasound-guided diagnosis and therapy of pancreatic cystic neoplasms

Gastrointestinal Intervention, 2017
This review highlights new developments in the field of endoscopic ultrasound (EUS)-guided diagnosis and therapy of pancreatic cystic neoplasms. Studies pertinent to pancreatic cyst diagnosis by morphology, namely diagnostic accuracies of various ...
Tejas Kirtane, Manoop S. Bhutani
doaj   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms.

, 2014
This report contains clinically oriented guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms in patients fit for treatment.
Arcidiacono P, Italian Association of Hospital Gastroenterologists, Villanacci V, Pasquali C, Manfredi G, D'Onofrio M, Zamboni G, Pacchioni D, PEZZILLI, RAFFAELE, Capurso G, Bocus P, Buscarini E, Italian Association for the Study of the Pancreas, Calculli L, Zerbi A, Ventrucci M, Angelis CD, PASQUALI, CLAUDIO, Endoscopists, Endoscopists AIGO, Frulloni L, Crippa S, CALCULLI, LUCIA, Cystic Pancreatic Neoplasm Study Group, Venturini S, Basso D, Canzonieri V, Barresi L, FUSAROLI, PIETRO, Morana G, Pezzilli R, Gion M, Balzano G, Falconi M, Cannizzaro R, Casadei R, Fusaroli P, Italian Association for the Study of the Pancreas AISP, CASADEI, RICCARDO, De Angelis C, Rocca R, BASSO, DANIELA   +41 more
core   +1 more source