Results 191 to 200 of about 297,195 (347)

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Clinicopathologic risk factors for post-operative complications after enucleation of pancreatic neoplasms. [PDF]

World J Surg Oncol
Madeka I, Yi S, Evans J, Baek D, Naringrekar HV, Lavu H, Yeo CJ, Nevler A, Bowne WB.   +8 more
europepmc   +1 more source

Intraductal papillary mucinous neoplasms: Does a family history of pancreatic cancer matter?

, 2012
Deepika Nehra, Vicente Morales Oyarvide, Mari Mino‐Kenudson, Sarah P. Thayer, Cristina R. Ferrone, Jennifer A. Wargo, Alona Muzikansky, Dianne M. Finkelstein, Andrew L. Warshaw, Carlos Fernández‐del Castillo   +9 more
openalex   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Impact of Patient Income and Insurance on Postoperative Mortality After Total Pancreatectomy for Pancreatic Neoplasms. [PDF]

J Surg Oncol
Vargas GM, Farooq MS, Shafique N, Lee MK, Vollmer CM, Miura JT, Karakousis GC.   +6 more
europepmc   +1 more source

Cystic jejunal duplication with Heinrich’s type I ectopic pancreas, incidentally discovered in a patient with pancreatic tail neoplasm

, 2016
Simona Gurzu, Tivadar Bara, Tivadar Bara, Annamária Fetykó, Ioan Jung   +4 more
openalex   +2 more sources

Treatment of malignant pancreatic neuroendocrine neoplasms: middle-term (2-year) outcomes of a prospective observational multicentre study [PDF]

, 2013
Alessandro Zerbi, Vanessa Capitanio, Letizia Boninsegna, Gianfranco Delle Fave, Claudio Pasquali, Guido Rindi, Davide Campana, Massimo Falconi   +7 more
openalex   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Ossification in pancreatic neoplasms: A report of three cases of neuroendocrine tumor, mucinous cystic neoplasm, and intraductal papillary mucinous neoplasm with review of the literature. [PDF]

Biomed Rep
Fukuma Y, Ishida M, Yasuda E, Nakanishi K, Kushiyama S, Tomioka A, Asakuma M, Hirose Y.   +7 more
europepmc   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source