Results 51 to 60 of about 297,195 (347)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors [PDF]

, 2012
BACKGROUND MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with pre-malignant pancreatic tumors.
A Cimmino, A Grimson, A Keller, A Lal, A Singh, Adam E. Frampton, AE Szafranska, AE Szafranska, AL Warshaw, AM Bellizzi, AM Krichevsky, AN Bartley, Andreas Keller, BM Bolstad, C Almoguera, C Galanis, C Mayr, C Stefano, D Bartsch, D Bonci, DS Klimstra, DV Sahani, F Takeshita, FA Sinicrope, G Garcea, GA Calin, Georgios Giamas, GK Smyth, GK Smyth, H Matthaei, H Wang, J Lu, J Meister, J Torrisani, J Yu, Jimmy Jacob, Jonathan Krell, JS Desgrosellier, JS Oh, Justin Stebbing, K Izeradjene, K Ohuchida, K Satoh, K Yoshizawa, KC Miranda, L Castellano, L Xia, Leandro Castellano, Long R. Jiao, Loredana Pellegrino, M Bloomston, M Crawford, M Dillhoff, M Fabbri, M Goggins, M Seux, M Tanaka, Marc Tjwa, MC du Rieu, N Abe, N Habbe, Nagy A. Habib, Nicole Tsim, O Basturk, OA Kent, Panagiotis Vlavianos, Patrizia Cohen, R Bhattacharya, R Feng, Raida Ahmad, RI Aqeilan, S Griffiths-Jones, S Griffiths-Jones, S Hamada, S Mukherjee, S Reddy, S Vorwerk, S Watanabe, S Yu, SD Selcuklu, SF Tavazoie, SM Johnson, SYG Friedlander, T Ishikawa, T Paranjape, WA Mardin, WG Zhao, WR Brugge, X Chen, X Li, Y Akao, Y Benjamini, Y Hochberg, YJ Chua   +93 more
core   +9 more sources

Recent developments in endoscopic ultrasound-guided ablation treatment

International Journal of Gastrointestinal Intervention, 2020
Endoscopic ultrasound (EUS)-guided fine-needle aspiration was introduced in the early 1990s. EUS has evolved from a diagnostic modality to a therapeutic tool for patients with various pancreatic neoplasms.
Hoonsub So, Dongwook Oh, Dong-Wan Seo
doaj   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Cystic Lesions of the Pancreas [PDF]

, 2014
With the increasing use of abdominal imaging, cystic lesions of the pancreas are being more frequently detected. These lesions may carry a significant premalignant potential.
Azzopardi, Neville
core  

Treatment of a mixed acinar-endocrine carcinoma with uptake on 68Gallium-DOTATOC positron emission tomography-computed tomography : a case report [PDF]

, 2017
The case of a 35-year old female patient with a diagnosis of metastatic mixed acinar-endocrine carcinoma (MAEC) is investigated in the present study.
De Both, Anneleen, De Man, Marc, Geboes, Karen, Hoorens, Anne, Troisi, Roberto, Van Vlierberghe, Hans   +5 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The rare case of a cystic pancreatic neuroendocrine tumor

Autopsy and Case Reports, 2021
The pancreatic neuroendocrine tumors (PanNETs) most commonly present as solid neoplasms; however, very rarely, they may present primarily as cystic neoplasms. Most of the cystic PanNETs are non-secreting tumors, and the radiological features are not well
Tarun Kumar, Brijnandan Gupta, Prasenjit Das, Kumble S. Madhusudhan   +3 more
doaj  

THE POSSIBILITIES OF ENDOSCOPIC ULTRASONOGRAPHY IN THE DIAGNOSTICS OF SOLID PANCREATIC NEOPLASMS

Кубанский научный медицинский вестник, 2018
Endosonography takes a leading role in solid pancreatic neoplasms diagnostics. This article presents the main indicators of diagnostics efficiency of the method depending on the nosology of a tumor.
N. S. Ryabin, A. N. Katrich, M. I. Bykov, R. G. Stash   +3 more
doaj   +1 more source