Results 121 to 130 of about 836,777 (260)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Perioperative Outcomes of Patients With Pancreatic Neuroendocrine Neoplasms in the Context of Different Body Composition Phenotypes

World Journal of Surgery, EarlyView.
Pancreatic neuroendocrine neoplasms (pNEN) are rare and heterogeneous tumors with increasing incidence. While surgical resection remains the only curative treatment, perioperative outcomes are influenced by patient‐related risk factors. Recent research highlights body composition (BC) as a prognostic marker in oncological and transplantation surgery ...
Fabiola A. Bechtiger, Mariah Herbrich, Hazem K. A. A. Hassan, Jörg Kaiser, Thomas Hank, Magdalena Lewosinska, Deniz Uluk, Osman Öcal, Nicole D. Hildebrand, Steven WM Olde Damink, Franck Billmann, Zoltan Czigany, Mohammed Al‐Saeedi   +12 more
wiley   +1 more source

Small Bowel Cancer: Implications of Preoperative Work‐Up on Surgical Strategy

World Journal of Surgery, EarlyView.
Small bowel cancers comprise a heterogeneous group of malignancies, making diagnosis and treatment challenging. This study aimed to evaluate the ability of preoperative diagnostic work‐up to predict clinical and histopathological findings, facilitate subgroup identification, and support tailored, individualized surgical strategies. Preoperative work‐up
Erik Kjæstad, Espen Thiis‐Evensen, Anita Sveen, Arne Olav Bakka, Johannes Kurt Schultz   +4 more
wiley   +1 more source

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

World Journal of Surgery, EarlyView.
There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challenging, especially when small intestinal neuroendocrine tumor (siNET) metastases give rise to ...
Erik Kjæstad, Espen Thiis‐Evensen, Bjørn Edwin, Arne Olav Bakka, Anne Helene Lilleaas, Yngve Thorsen, Johannes Kurt Schultz   +6 more
wiley   +1 more source

Medication Related Osteonecrosis of the Jaw: Knowledge, Attitudes and Practice Patterns Among Australian Dental Practitioners

Australian Dental Journal, EarlyView.
ABSTRACT Background Medication related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive and antiangiogenic therapies. As the use of these medications continues to increase, dental practitioners play a critical role in prevention and management of at‐risk patients. This survey evaluated the awareness, knowledge
Ying Shi Chang, Christopher Friel, Gary Low, Albert Yaacoub, Stephen Clive Cox   +4 more
wiley   +1 more source

[Pancreatic neuroendocrine tumors].

Revista medica de Chile, 2005
All pancreatic neuroendocrine tumors derive from Langerhans islet cells and have a low incidence. Half of them are functioning tumors that produce diverse hormones and occasionally cause serious clinical endocrine syndromes. They may be malignant, but they have a better survival, if compared to pancreatic ductal adenocarcinoma.
Luis, Burgos, María Eugenia, Burgos
openaire   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Emerging use of everolimus in the treatment of neuroendocrine tumors

, 2017
Pablo Gajate, Olga Martínez-Sáez, Teresa Alonso-Gordoa, Enrique Grande Medical Oncology Department, Ramon y Cajal University Hospital, Madrid, Spain Abstract: Neuroendocrine tumors (NETs) consist of a diverse family of malignancies, which ...
Grande E, Martínez-Sáez O, Alonso-Gordoa T, Gajate P   +3 more
core  

Therapy for metastatic pancreatic neuroendocrine tumors

, 2014
Pancreatic neuroendocrine tumors (pNETs) are frequently malignant (50-80%, except for insulinoma) and may show an aggressive course with metastases to the liver as well as more distant sites.
D. Conte, R.E. Rossi, S. Massironi, M. Peracchi   +3 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source