Enhancement of the activity of the antimicrobial peptides HNP1 and LL-37 by bovine pancreatic ribonuclease A [version 3; peer review: 1 approved, 2 approved with reservations, 1 not approved] [PDF]
F1000Research, 2023 Background: HNP1, LL-37, and HBD1 are antimicrobial against Escherichia coli ATCC 25922 at the standard inoculum but less active at higher inocula. Methods: The virtual colony count (VCC) microbiological assay was adapted for high inocula and the ...
Bryan Ericksen
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Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K [PDF]
BMC Chemistry, 2023 The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = 0.77 Å). This is the first ultra-high-resolution structure of
David R. Lisgarten +9 more
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Specific Targeting of Recombinant Human Pancreatic Ribonuclease 1 using Gonadotropin-Releasing Hormone Targeting Peptide toward Gonadotropin-Releasing Hormone Receptor-Positive Cancer Cells [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Targeted drug delivery is a novel method to specifically deliver anticancer therapeutics to tumor sites. Gonadotropin-releasing hormone (GnRH) is a decapeptide, and its target binding property has attracted attention as a means of targeted ...
Amir Maleksabet +4 more
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Carbohydrate in Pancreatic Ribonucleases [PDF]
European Journal of Biochemistry, 1976 A survey of the presence and compositions of carbohydrate chains attached to pancreatic ribonucleases is given. Carbohydrate chains may occur at asparagine residues in Asn-X-Ser/Thr sequences at four exposed sites of the molecule (positions 21, 34, 62 and 76).
BEINTEMA, JJ +3 more
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Functional role of glutamine 28 and arginine 39 in double stranded RNA cleavage by human pancreatic ribonuclease. [PDF]
PLoS ONE, 2011 Human pancreatic ribonuclease (HPR), a member of RNase A superfamily, has a high activity on double stranded (ds) RNA. By virtue of this activity HPR appears to be involved in the host-defense against pathogenic viruses.
Md Tabish Rehman +4 more
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Human Pancreatic Ribonuclease [PDF]
European Journal of Biochemistry, 1997 Mammalian ribonucleases constitute one of the fastest evolving protein families in nature. The addition of a four‐residue carboxyl‐terminal tail: Glu‐Asp‐Ser‐Thr (EDST) in human pancreatic ribonuclease (HPR) in comparison with bovine pancreatic RNase (RNase A) could have adaptive significance in humans.
H P, Bal, J K, Batra
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Molecular evolution of pancreatic-type ribonucleases. [PDF]
Molecular Biology and Evolution, 1986 Amino acid sequences of 39 mammalian ribonucleases have been used to construct trees by the maximum parsimony procedure. These trees are in fairly good agreement with the biological classification of the species involved. In the branching order of the six investigated eutherian mammalian orders, the edentates diverge first, followed, probably, by the ...
BEINTEMA J. J. +2 more
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Molecular dynamics simulation of bovine pancreatic ribonuclease A-CpA and transition state-like complexes. [PDF]
J Phys Chem B, 2010 Formoso E, Matxain JM, Lopez X, York DM.
europepmc +3 more sources
Screening of Pancreatic Ribonuclease A Inhibitors from an Autodisplayed Fv-Antibody Library. [PDF]
ACS Pharmacol Transl Sci, 2023 Sung JS +7 more
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Strangulated Inguinal Hernia Containing Caecum and Inflamed Appendix: Two Case Reports and Review of the Literature to Guide Management [PDF]
Journal of Abdominal Wall SurgeryIntroductionAmyand’s hernia is defined by the presence of the appendix in the sac of an inguinal hernia. Its treatment poses two problems: the risk of infection associated with the presence of the appendix and the choice of surgical technique, which must
Guillaume Tcheutchoua Soh +15 more
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