Results 121 to 130 of about 22,977 (294)

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

open access: yesGlia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller   +11 more
wiley   +1 more source

A CHROMATOGRAPHIC INVESTIGATION OF PANCREATIC RIBONUCLEASE [PDF]

open access: yesJournal of Biological Chemistry, 1953
Stanford Moore   +2 more
openaire   +2 more sources

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

open access: yesGlia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri   +8 more
wiley   +1 more source

On the Sequence of Residues 11 to 18 in Bovine Pancreatic Ribonuclease

open access: hybrid, 1962
Derek G. Smyth   +2 more
openalex   +1 more source

A promising frontier of circulating messenger RNA in liquid biopsy: From mechanisms to clinical applications

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Liquid biopsy can revolutionize cancer patient management as repeated sampling allows real‐time monitoring of disease progression and response to treatment. The circulating transcriptome represents a rich source of potential cancer biomarkers, including coding and non‐coding RNAs.
Mengqian Li   +7 more
wiley   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Characterization of Sirt2 using conditional RNAi in mice [PDF]

open access: yes, 2011
Within the past eight years, RNA interference (RNAi) has emerged as a powerful experimental tool for gene function analysis in mice. Reversible control of shRNA mediated RNAi has been achieved by using a tetracycline (tet)-inducible promoter.
Reiss, Martina
core  

The Isolation of Porcine Ribonuclease, a Glycoprotein, from Pancreatic Juice

open access: hybrid, 1968
V N Reinhold   +5 more
openalex   +1 more source

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