Results 151 to 160 of about 22,977 (294)

The primary structure of giraffe pancreatic ribonuclease [PDF]

open access: yesFEBS Letters, 1974
Gerda Groen   +3 more
openaire   +3 more sources

A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults

open access: yesAging Cell, EarlyView.
We derived a 25‐protein blood‐based frailty signature (proteomic frailty index, pFI) predictive of the cumulative frailty index. The pFI was validated across independent cohorts and was significantly associated with physical, clinical, and cognitive function, as well as incident mortality and dementia, highlighting its potential as a biomarker of ...
Sanish Sathyan   +13 more
wiley   +1 more source

Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma

open access: yesAllergy, EarlyView.
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong   +217 more
wiley   +1 more source

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

open access: yesBrain Pathology, EarlyView.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon   +5 more
wiley   +1 more source

Polarity Gene PARD6B Promotes Tumor Growth of Colorectal Cancer via Increasing MYC Expression

open access: yesCancer Science, EarlyView.
Partitioning Defective 6B (PARD6B), a polarity gene, functions as a scaffold node for the Par protein complex. In this study, we showed that highly expressed PARD6B could promote CRC growth by upregulating MYC expression while suppressing miR‐34c expression.
Kosuke Hirose   +18 more
wiley   +1 more source

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