On the Preparation of Bovine Pancreatic Ribonuclease A
Journal of Biological Chemistry, 1963 Arthur M. Crestfield +2 more
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Affinity Labeling of Pancreatic Ribonuclease
Journal of Biological Chemistry, 1971 Abstract Pyridoxal phosphate can be firmly bound by reduction with sodium borohydride to many enzymes in which it occurs. Such treatment has been used to label specifically parts of peptide chains in the vicinity of the bound coenzyme. Pyridoxal phosphate may form specific complexes with many proteins for which it has no known coenzyme function. Bovine
Gary E. Means, Robert E. Feeney
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Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic [PDF]
مجله بیوتکنولوژی کشاورزی, 2021 Objective Immunotoxins are one of the most promising ways in therapeutic fields, specially cancer therapy which have a unique toxin-antibody structure, and kill the cancer cell by passing through the cell membrane and entering the target cell.
Masoume Vakili-Azghandi +3 more
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Horse Pancreatic Ribonuclease [PDF]
European Journal of Biochemistry, 1974 Horse ribonuclease was purified after acid extraction of pancreas by ammonium sulfate fractionation and chromatography on CM‐cellulose. It is a glycoprotein with an average molecular weight of about 18000. The pure enzyme was chromatographically and electrophoretically heterogeneous due to the heterogeneity of the carbohydrate moiety.The amino‐acid ...
A. J. Scheffer, Jaap J. Beintema
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MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy. [PDF]
PLoS ONE, 2013 Novel data showing an important role of microRNAs in mediating tumour progression opened a new field of possible molecular targets for cytotoxic ribonucleases.
Nadezhda Mironova +5 more
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A novel circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk in pancreatic cancer
Autoimmunity, 2021 Background Pancreatic cancer is a lethal malignancy in both sexes throughout the world. Circular RNAs (circRNAs) have been implicated in the development of pancreatic cancer by operating as competing endogenous RNAs (ceRNAs).
Yang Wang +5 more
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Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]
, 2020 Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
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Intramolecular interactions in pancreatic ribonucleases [PDF]
Protein Science, 1992 AbstractA detailed analysis of the composition and properties of hydrophobic nuclei and microclusters in pancreatic ribonuclease A (RNase A) has been carried out. Distance calculations for all noncovalently bonded atoms revealed that the average number of nonpolar contacts between a side chain of an amino acid and its neighbors is substantially larger ...
Bangalore K. Sathyanarayana +3 more
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A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases
Journal of Biomedical Science, 2018 Pancreatic ribonuclease is known to participate in host defense system against pathogens, such as parasites, bacteria, and virus, which results in innate immune response. Nevertheless, its potential impact to host cells remains unclear.
Ying-Nai Wang +2 more
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Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway [PDF]
, 2014 In contrast to molecular chaperones that couple protein folding to ATP hydrolysis, protein disulfide-isomerase (PDI) catalyzes protein folding coupled to formation of disulfide bonds (oxidative folding).
A Jansens +54 more
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