Results 191 to 200 of about 22,977 (294)

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer [PDF]

, 2018
Ying‐Nai Wang, Heng‐Huan Lee, Chao‐Kai Chou, Wenhao Yang, Yongkun Wei, Chun‐Te Chen, Jun Yao, Jennifer L. Hsu, Cihui Zhu, Haoqiang Ying, Yuanqing Ye, Wei‐Jan Wang, Seung-Oe Lim, Weiya Xia, How-Wen Ko, Xiuping Liu, Chang‐Gong Liu, Xifeng Wu, Huamin Wang, Donghui Li, Laura R. Prakash, Matthew H. G. Katz, Ya’an Kang, Michael P. Kim, Jason B. Fleming, David R. Fogelman, Milind Javle, Anirban Maitra, Mien‐Chie Hung   +28 more
openalex   +1 more source

Patient‐derived tumor organoids highlight the potential of precision medicine in managing pancreatic ductal adenocarcinoma

International Journal of Cancer, Volume 157, Issue 4, Page 760-772, 15 August 2025.
What's new? Only about one‐fifth of patients with pancreatic ductal adenocarcinoma (PDAC) qualify for curative treatment approaches employing adjuvant chemotherapy. Tools to predict PDAC response to chemotherapeutic regimens, however, are lacking.
Christine Nitschke, Charline Phan, Yara Souto, Philipp Walter, Mara Goetz, Gediminas Simkus, Jacob Thastrup, Ronald Simon, Jürgen Kupper, Jakob Izbicki, Steven A. Johnsen, Thilo Hackert, Marianne Sinn, Harriet Wikman, Faik G. Uzunoglu, Tabea M. Sturmheit   +15 more
wiley   +1 more source

Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review). [PDF]

Mol Med Rep
Wang L, Zhang J, He Z, Kong X, Liu C, Xia Y, Yang M, Wang K.   +7 more
europepmc   +1 more source

PO-427 A nuclear-directed human pancreatic ribonuclease variant is cytotoxic for breast cancer cells cultured in 3D and kills cancer stem cells [PDF]

, 2018
Jessica Castro, Antoni Benito, María Vilanova, Marc Ribó, Giusy Tornillo, Matthew J. Smalley   +5 more
openalex   +1 more source

Effective RNA Complexation by [2]Catenanes Confers Enhanced Resistance to Enzymatic Degradation

Chemistry – A European Journal, Volume 31, Issue 45, August 13, 2025.
Peptide‐based cationic [2]catenanes are resistant to proteases and efficiently complex siRNA, providing protection from degradation by nucleases. Abstract Cationic [2]catenanes bearing l‐arginine residues were synthesized via dynamic covalent self‐assembly in water.
Dimitri Delcourt, José García Coll, Fabien B. L. Cougnon, Sébastien Ulrich   +3 more
wiley   +1 more source

From Solution to Gas Phase: Revealing Ligand-Dependent Conformations of Ribonuclease A with Tandem-Trapped Ion Mobility Spectrometry. [PDF]

JACS Au
Liu FC, Chai M, Qu T, Cropley TC, Zheng L, Yang W, Bleiholder C.   +6 more
europepmc   +1 more source

Structure and dynamic behavior of the oligosaccharide side chain of bovine pancreatic ribonuclease B. Application of carbon 13 nuclear magnetic resonance spectroscopy.

, 1981
Elisha Berman, D. Eric Walters, Adam Allerhand   +2 more
openalex   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Amino acids and peptides. XII. Synthesis of C-terminal decapeptide of bovine pancreatic ribonuclease A(RNase A) and its analogs and determination of their ability to reactivate des(121-124)RNase A.

, 1984
Yoshio Okada, Naoki Teno, J Miyao, Yumiko Mori, Masachika IRIE   +4 more
openalex   +2 more sources

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source