Results 201 to 210 of about 22,977 (294)

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis. [PDF]

World J Gastroenterol
Zhang J, Ou CL.
europepmc   +1 more source

Clotting and other plasma factors in septicemia [PDF]

, 1980
Fritz, Hans, Jochum, Marianne, Peeters, Hubert, Schießler, Hans, Witte, J.   +4 more
core  

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, Volume 12, Issue 29, August 7, 2025.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis. [PDF]

BMC Mol Cell Biol
Kabir KMA, Takahashi T, Kikuchi T.
europepmc   +1 more source

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

BioEssays, Volume 47, Issue 8, August 2025.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source

Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution. [PDF]

Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Larson SB, Day JS, Nguyen C, Cudney R, McPherson A.   +4 more
europepmc   +1 more source

Catalysis of the Oxidative Folding of Bovine Pancreatic Ribonuclease A by Protein Disulfide Isomerase

, 2000
Hang‐Cheol Shin, Harold A. Scheraga
openalex   +1 more source

Targeting the mTOR Signaling Pathway Through miR‐100 and miR‐101 in De Novo Acute Myeloid Leukemia: Implications for Therapeutic Intervention

Cancer Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background Microribonucleic acid (MicroRNAs/miRNAs) play a significant role in cancer progression by changing cellular functions through the modulation of protein expressions. The potential of different miRNAs to alter the expression of the mammalian target of rapamycin (mTOR)/protein kinase B (PKB or AKT)/phosphatidylinositol‐3‐kinase (PI3K ...
Maryam Kargar, Mehdi Allahbakhshian Farsani, Javad Garavand, Mahnaz Gorji, Mohammad Rafiee, Seyed Sobhan Bahreiny, Mohammad Hossein Mohammadi   +6 more
wiley   +1 more source

Pancreatic Comorbidities in Pediatric Celiac Disease: Exocrine Pancreatic Insufficiency, Pancreatitis, and Diabetes Mellitus. [PDF]

Diagnostics (Basel)
Poddighe D.
europepmc   +1 more source

Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study

International Journal of Gynecology &Obstetrics, Volume 170, Issue 2, Page 774-782, August 2025.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya, Eissa Almaghrebi, Fatma Akat, Eda Nur Hepbildi, Esra Kosucu, Muslu Kazım Körez, Husamettin Vatansev   +6 more
wiley   +1 more source