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Human pancreatic ribonuclease presents higher endonucleolytic activity than ribonuclease A
Archives of Biochemistry and Biophysics, 2008Analyzing the pattern of oligonucleotide formation induced by HP-RNase cleavage shows that the enzyme does not act randomly and follows a more endonucleolytic pattern when compared to RNase A. The enzyme prefers the binding and cleavage of longer substrate molecules, especially when the phosphodiester bond that is broken is 8-11 nucleotides away from ...
M, Rodríguez +5 more
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Serum Deoxyribonuclease and Ribonuclease in Pancreatic Cancer and Chronic Pancreatitis
Tumori Journal, 1985Serum ribonuclease (RNase) and deoxyribonuclease (DNase) were investigated in 18 control subjects, and in 22 patients with pancreatic cancer, 13 with chronic pancreatitis and 29 with extrapancreatic diseases in order to assess their clinical usefulness in pancreatic cancer diagnosis and to evaluate whether modifications were consensual and/or age ...
BASSO, DANIELA +7 more
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Newly observed binding mode in pancreatic ribonuclease
Journal of Molecular Biology, 1992Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the ...
C F, Aguilar +4 more
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24 Bovine Pancreatic Ribonuclease
1971Publisher Summary This chapter discusses the process of isolation, chromatography, structure, and molecular and catalytic properties of bovine pancreatic ribonuclease. At present there are three simple and widely used chromatographic procedures: (1) Hirs base their method on the carboxyl ion exchange resin IRC-50 with 0.2 M phosphate buffer pH 6.45 ...
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Research on Pancreatic Ribonuclease
The Journal of Biochemistry, 1961TYUNOSIN UKITA +2 more
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Ribonuclease Activity of Pancreatic Extracts
New England Journal of Medicine, 1977W A, Gahl, P J, Chesney, H C, Pitot
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Research on Pancreatic Ribonuclease
The Journal of Biochemistry, 1964TYUNOSIN UKITA, KEIZO WAKU
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