Results 21 to 30 of about 24,475 (262)

A novel circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk in pancreatic cancer

Autoimmunity, 2021
Background Pancreatic cancer is a lethal malignancy in both sexes throughout the world. Circular RNAs (circRNAs) have been implicated in the development of pancreatic cancer by operating as competing endogenous RNAs (ceRNAs).
Yang Wang, Feng Zhang, Dongde Wu, Qun Wang, Lei Nie, Jing Yu   +5 more
doaj   +1 more source

Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]

, 2020
Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
core   +1 more source

Intramolecular interactions in pancreatic ribonucleases [PDF]

Protein Science, 1992
AbstractA detailed analysis of the composition and properties of hydrophobic nuclei and microclusters in pancreatic ribonuclease A (RNase A) has been carried out. Distance calculations for all noncovalently bonded atoms revealed that the average number of nonpolar contacts between a side chain of an amino acid and its neighbors is substantially larger ...
, Kolbanovskaya EYu, B K, Sathyanarayana, A, Wlodawer, , Karpeisky MYa   +3 more
openaire   +2 more sources

Human pancreatic ribonuclease 1 [PDF]

Cancer, 2000
Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pancreatic adenocarcinoma tissues by immunohistochemical analysis and in situ hybridization (ISH ...
R, Peracaula, K R, Cleary, J, Lorenzo, R, de Llorens, M L, Frazier   +4 more
openaire   +3 more sources

A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

Journal of Biomedical Science, 2018
Pancreatic ribonuclease is known to participate in host defense system against pathogens, such as parasites, bacteria, and virus, which results in innate immune response. Nevertheless, its potential impact to host cells remains unclear.
Ying-Nai Wang, Heng-Huan Lee, Mien-Chie Hung   +2 more
doaj   +1 more source

Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway [PDF]

, 2014
In contrast to molecular chaperones that couple protein folding to ATP hydrolysis, protein disulfide-isomerase (PDI) catalyzes protein folding coupled to formation of disulfide bonds (oxidative folding).
A Jansens, A Land, A Pirneskoski, A. Katrine Wallis, Alistair G. Irvine, AR Karala, AR Karala, AY Denisov, B van den Berg, B van den Berg, B van den Berg, CB Anfinsen, Claudia A. Blindauer, CPM van Mierlo, CPM van Mierlo, CW Gruber, DP Goldenberg, E van Anken, F Hatahet, G Kozlov, G Wagner, HC Shin, HC Shin, J Riemer, JH Laity, JL Arolas, JS Weissman, JS Weissman, L Wang, LJ Byrne, Lloyd W. Ruddock, M Narayan, Mark J. Howard, Michelle L. Rowe, Narinder Sanghera, NJ Bulleid, NJ Darby, P Klappa, P Venetianer, RA Williamson, RB Freedman, RF Goldberger, Richard A. Williamson, RJ Ellis, Robert B. Freedman, S Masui, S Talluri, Salvador Ventura, TE Creighton, TE Creighton, TE Creighton, TE Creighton, VD Nguyen, VD Nguyen, WF Vranken   +54 more
core   +3 more sources

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]

, 2015
RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia, Urayama, Shiro, Wang, Wei-Peng, Yu, Ai-Ming, Zeng, Su   +4 more
core   +2 more sources

Study Levels of Some Biochemical Parameters in Serum of Pancreatic Cancer Patients

Tikrit Journal of Pure Science, 2018
This study included an estimation for the levels of some biochemical parameters in the serum of those pancreatic cancer patients, by collecting (40) blood samples from patients their ages ranged (30-70) years compared with (55) blood samples of healthy ...
Layla A. Mustafa, Zena A. Mohammad
doaj   +1 more source

The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27^KIP1

Molecules, 2021
Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo, Jessica Castro, Jesús Matés, Marlon Bravo, Marc Ribó, Maria Vilanova, Antoni Benito   +6 more
doaj   +1 more source

A possible mechanism for cold denaturation of proteins at high pressure [PDF]

, 2003
We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where
A. Hansen, A. Trovato, B. L. Chen, B. L. Chen, B. Lee, C -J. Tsai, C. N. Pace, C. Vanderzande, D. Chandler, E. Paci, F. H. Stillinger, G. Caldarelli, G. Hummer, G. P. Privalov, G. Panick, G. W. Robinson, H. Ludwing, H. S. Chan, H. S. Frank, J. Jonas, J. Zhang, J. Zipp, K. A. Dill, K. A. Dill, K. A. Dill, K. A. Dill, K. A. T. Silverstein, K. C. Cho, K. F. Lau, L. R. Pratt, L. Smeller, M. W. Mahoney, N. Muller, O. Collet, P. Bruscolini, P. L. Privalov, P. L. Privalov, P. R. ten Wolde, P. R. ten Wolde,, R. A. Pierotti, S. A. Hawley, S. A. Hawley, S. Chan, S. J. Gill, S. Kunugi, S. Shimizu, S. Shimizu, V. A. Payne, V. F. Petrenko, W. Kauzmann, Y. Nozaki   +50 more
core   +3 more sources