Results 81 to 90 of about 22,977 (294)

Gemcitabine exhibits a suppressive effect on pancreatic cancer cell growth by regulating processing of PVT1 to miR1207

Molecular Oncology, 2018
Gemcitabine serves as a first‐line chemotherapy agent for advanced pancreatic cancer (PC). However, the molecular basis by which gemcitabine exerts its effects is not well‐established, and the targeted genetic pathways remain unclear.
Lei You, Huanyu Wang, Gang Yang, Fangyu Zhao, Jingcheng Zhang, Ziwen Liu, Taiping Zhang, Zhiyong Liang, Changzheng Liu, Yupei Zhao   +9 more
doaj   +1 more source

Condensation of Cytidylic Acid in the Presence of Polyphosphoric Acid [PDF]

Condensation of cytidylic acid in presence of polyphosphoric ...
Fox, S. W., Schwartz, A. W.
core   +1 more source

The nucleotide sequences of two tryptophane-tRNAs from brewer's yeast [PDF]

, 1971
The study entitled “Observance of PMC and Its Relation to the Presence of Three Levels of Politeness” investigates politeness realizations according to Principles of Mutual Consideration (PMC) between two different cultures and its relation to the ...
Keith, G., Roy, A., Ebel, J.P., Dirheimer, G.   +3 more
core   +4 more sources

Gut Parabacteroides distasonis‐derived Indole‐3‐Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR‐FASN Axis in Bladder Cancer

Advanced Science, EarlyView.
Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li, Wentai Shangguan, Wenxue Huang, Jie Zhao, Yuexuan Zhu, Ming Xie, Yao Yu, Qishen Yang, Jun Zheng, Lin Yang, Qi Sun, Leqian Li, Xinhang Shi, Yongyuan Xiao, Hai Huang, Bisheng Cheng, Peng Wu   +16 more
wiley   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Screening of Pancreatic Ribonuclease A Inhibitors from an Autodisplayed Fv-Antibody Library. [PDF]

ACS Pharmacol Transl Sci, 2023
Sung JS, Jung J, Hwang H, Bong JH, Kang MJ, Jose J, Lee M, Pyun JC.   +7 more
europepmc   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Protein disulphide isomerase-assisted functionalization of proteinaceous substrates [PDF]

, 2012
Protein disulphide isomerase (PDI) is an enzyme that catalyzes thiol-disulphide exchange reactions among a broad spectrum of substrates, including proteins and low-molecular thiols and disulphides.
Anfinsen CB, Araújo R, Artur Cavaco-Paulo, Barba C, Barbieri L, Bartlett AI, Bass R, Bauhuber S, Berisio R, Bhushan B, Block RJ, Bradbury JH, Brandelli A, Brockway BE, Brown KC, Bryngelson JD, Bulaj G, Cabral CM, Cavaco Paulo A, Cavaco-Paulo AM, Chivers PT, Cortez J, Cortez J, Creighton TE, Creighton TE, Creighton TE, Cunnea PM, Danciulescu C, DebBurman SK, Dobson C, Dybdal Lone, Edman JC, Ellgaard L, Fassio A, Fernandes MM, Fernandes MM, Feughelman M, Forster S, Franbourg A, Franbourg A, Frand AR, Freedman RB, Fu P, Fujii T, Gedanken A, Gilbert HF, Goldberger RF, Gosselin M A, Gough JD, Gray J, Hadas A, Harper JD, Hartl FU, Hatahet F, Hawkins HC, Heine E, Holmgren A, Hoshino M, Ishida T, Jones LN, Jungbauer A, Kakizawa Y, Katoh K, Kim PS, King RD, King T, Kittle PAC, Klappa P, Koehn H, Koo EH, Kortemme T, Kulp MS, Kurimoto A, Leonidas DD, Li J, Lillig CH, Lundstroem J, Lyles MM, Lyles MM, Margarida M. Fernandes, Matousek J, Mazzarella RA, Mcdevitt J, McKenzie D L, Moore EC, Moore KJ, Moss J, Murkofsky NA, Naeem M, Negri AP, Neira JL, Onuchic JN, O’Connor SD, Parry DAD, Pigiet VPNS, Pille L, Pilot-Matias TJ, Plowman JE, Plowman JE, Pollard MG, Puskas JE, Raines RT, Reinhardt C, Riffel A, Rippon J, Rothwarf DM, Rouse JG, Saito G, Sevier CS, Sierpinski P, Silva CJ, Silva CJSM, Silva CJSM, Smith TA, Soucek J, Steiner RF, Swift JA, Tachibana A, Tan CJ, Tanabe T, Taniyama Y, Teale JM, Thomas PJ, Varandani PT, Varandani PT, Vasconcelos A, Venetianer P, Walker KW, Wang C-C, Wedemeyer WJ, Weissman J, Welker E, Wilkinson B, Wilson RH, Witt D, Wolfram LJ, Wunderlich M, Wyckoff HW, Wysocki AP, Yamauchi K, Yamauchi K, Zimek A, Zoccola M, Åslund F   +143 more
core   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source