Results 81 to 90 of about 62,490 (297)
Advanced Science, EarlyView.Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen +14 more
wiley +1 more source
Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. [PDF]
, 2016 Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however ...
Bhushan, Anil +3 more
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Advanced Science, EarlyView.The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan +16 more
wiley +1 more source
Majalah Kedokteran Andalas, 2011 AbstrakPseudokista Pankreas merupakan penumpukan cairan yang terlokalisir yang kaya amilase dan enzim pankreas lainnya, yang memiliki dinding yang tidak berepitel. Ukuran bervariasi 2-30 cm. Sekitar sepertiga dari pseudokista terjadi pada caput pankreas,
Asril Zahari, Fahmi Fahmi
doaj +1 more source
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
Frontiers in SurgeryBackgroundPancreatic trauma is a rare solid organ injury. Conservative treatment is often indicated in patients with no pancreatic duct injury, while patients with high-grade pancreatic damage most often require surgical intervention.
Xitao Wang +3 more
doaj +1 more source
Research Advances: January 2014 [PDF]
, 2014 The VA has a comprehensive research agenda to help the newest generation of Veterans -- those returning from operations Enduring Freedom, Iraqi Freedom, and New Dawn.
core
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
The use of MRI digital subtraction technique in the diagnosis of traumatic pancreatic injury
Radiology Case Reports, 2019 Traumatic pancreatic injuries are relatively uncommon in the setting of trauma, however, early detection of these injuries can alter patient management and overall prognosis. Computed tomography is the first line imaging modality in major trauma. Because
Caroline Hubbard, BS +2 more
doaj +1 more source
Surgical management of blunt pancreatic trauma: A modus operandi or individualized therapy? [PDF]
, 2008 The overall rate of blunt pancreatic trauma observed in level one trauma centers is rather low compared to other injuries, with a reported prevalence of 0.4 per 100,000 hospital admissions.
Ejaz, Kiran, Khan, Muhammad Rizwan
core +1 more source