Results 71 to 80 of about 3,217,495 (250)

Quality of life in patients with comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease in presence of smoking

Infusion & Chemotherapy, 2019
Background. A combination of chronic pancreatitis and chronic obstructive pulmonary disease is quite common in clinical practice. This has a negative effect on the clinical course of both diseases.
L. S. Babinets, О. S. Kvasnitska
doaj   +1 more source

Pathophysiology of acute experimental pancreatitis: Lessons from genetically engineered animal models and new molecular approaches [PDF]

, 2005
The incidence of acute pancreatitis is growing and worldwide population-based studies report a doubling or tripling since the 1970s. 25% of acute pancreatitis are severe and associated with histological changes of necrotizing pancreatitis. There is still
Anne Barbara Tietz, Arnush M, Bhagat L, Bhatia M, Bhatia M, Bockman DE, Burkhard Göke, Claus Schäfer, Demols A, Ebert MP, Frossard JL, Gardner JD, Gerard C, Grady T, Grisham M, Gu D, Gukovskaya AS, Gukovsky I, Hahm KB, Halangk W, Halangk W, Korc M, Lee MS, Leser HG, Massague J, Meda P, Norman J, Ohnishi H, Ohnishi H, Ohnishi H, Roberts AB, Saluja A, Schafer C, Schafer C, Schmid RM, Song AM, Steinle A, Van Acker GJD, Vogelmann R   +38 more
core   +1 more source

Diagnosing Chronic Pancreatitis [PDF]

Digestive Diseases and Sciences, 2017
Diagnosing CP can range from routine in those with severe disease and obvious calcifications on CT imaging to elusive in those patients with early changes in CP. The workup of suspected CP should follow a progressively noninvasive to more invasive STEP-wise approach in a patient with a suspicious clinical presentation and risk factors that raise their ...
Ahmad Anaizi, Phil A. Hart, Darwin L. Conwell   +2 more
openaire   +2 more sources

Chronic pancreatitis: review and update of etiology, risk factors, and management

F1000Research, 2018
Chronic pancreatitis is a syndrome involving inflammation, fibrosis, and loss of acinar and islet cells which can manifest in unrelenting abdominal pain, malnutrition, and exocrine and endocrine insufficiency.
A. Pham, C. Forsmark
semanticscholar   +1 more source

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source

The association of statin use after cancer diagnosis with survival in pancreatic cancer patients: a SEER-medicare analysis. [PDF]

, 2015
BackgroundPancreatic cancer has poor prognosis and existing interventions provide a modest benefit. Statin has anti-cancer properties that might enhance survival in pancreatic cancer patients.
Cook-Wiens, Galen, Goodman, Marc T, Gottlieb, Roberta A, Jeon, Christie Y, Merz, C Noel Bairey, Pandol, Stephen J, Wu, Bechien   +6 more
core   +2 more sources

Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice

Gut, 2018
Objective Chronic pancreatitis is a progressive, relapsing inflammatory disorder of the pancreas, which often develops in the background of genetic susceptibility.
E. Hegyi, M. Sahin-Tóth
semanticscholar   +1 more source

Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. [PDF]

, 2016
First line treatment for pancreatic cancer consists of surgical resection, if possible, and a subsequent course of chemotherapy using the nucleoside analogue gemcitabine.
Barile, Elisa, Das, Swadesh K, De, Surya K, Emdad, Luni, Fisher, Paul B, Morvaridi, Susan Kharagh, Pandol, Stephen J, Pellecchia, Maurizio, Quinn, Bridget A, Sarkar, Devanand, Stebbins, John L, Wang, Si   +11 more
core   +2 more sources

A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

Nature Communications, 2018
Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target.
A. Geisz, M. Sahin-Tóth
semanticscholar   +1 more source

Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis

Animals, 2020
Pain management during in vivo experiments is an animal welfare concern and is in many countries also legally required. In this study, we evaluated C57Bl/6J mice when 3 g/L metamizole or 1 g/L tramadol was provided via drinking water, before and during ...
Guanglin Tang, Wiebke-Felicitas Nierath, Rupert Palme, Brigitte Vollmar, Dietmar Zechner   +4 more
doaj   +1 more source