Results 101 to 110 of about 472,362 (405)

Characterization of inflammatory pseudotumors in a large animal model of liver cancer

Animal Models and Experimental Medicine, EarlyView.
CT images in arterial and portal venous phases of liver lesions in Oncopig. Abstract Background The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been
Erik N. K. Cressman, Samantha Hicks, Natalie W. Fowlkes, Danielle L. Stolley, Maria Sophia Stenkamp   +4 more
wiley   +1 more source

Infected Necrosis in Severe Pancreatitis - Combined Nonsurgical Multi-Drainage with Directed Transabdominal High-Volume Lavage in Critically Ill Patients [PDF]

, 2009
Background: Infection of pancreatic necrosis is a life-threatening complication during the course of acute pancreatitis. In critically ill patients, surgical or extended endoscopic interventions are associated with high morbidity and mortality. Minimally
A. Meining, A. Umgelter, Baron, Beger, Bradley, Bradley, Branum, C. Prinz, Connor, Connor, Dellinger, Fernandez-del Castillo, Hartwig, Isenmann, J. Gaa, L. Ludwig, M. Bajbouj, McKay, Nathens, Nordback, R.M. Schmid, Sand, Sarr, Seewald, Seifert, Seifert, Tsiotos, Tzovaras, V. Becker, W. Huber, Werner, Whitcomb   +31 more
core   +1 more source

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Klebsiella predominance in peripancreatic microbial spectrum is associated with the severity of infected pancreatic necrosis

BMC Infectious Diseases
Background Infectious pancreatic necrosis (IPN) is associated with the prognosis of acute pancreatitis (AP). The correlation between microbial diversity in the peripancreatic region and AP severity remains unclear.
Xiaolan Guo, Yao Xu, Kaiwei Li, Jingzhu Zhang, Zhihui Tong, Weiqin Li, Donghuang Hong   +6 more
doaj   +1 more source

Coagulopathy and acute pancreatitis: pathophysiology and clinical treatment

Frontiers in Immunology
Coagulopathy is a critical pathophysiological mechanism of acute pancreatitis (AP), arising from the complex interplay between innate immune, endothelial cells and platelets.
Lan Li, Lan Li, Qingyuan Tan, Qingyuan Tan, Xueying Wu, Xiaowen Mou, Xiaowen Mou, Ziqi Lin, Tingting Liu, Wei Huang, Wei Huang, Lihui Deng, Tao Jin, Tao Jin, Qing Xia, Qing Xia   +15 more
doaj   +1 more source

Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets

Toxics
Acute pancreatitis (AP), induced by tetracycline, a widely used antibiotic, poses significant clinical and toxicological challenges, yet its molecular mechanisms remain unclear.
Hang Lei, Yimao Wu, Wenjun Ma, Jiaqi Yao, Pengcheng Zhang, Yong Tian, Yuhong Jiang, Zhijun Xie, Lv Zhu, Wenfu Tang   +9 more
doaj   +1 more source

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Frontiers in Physiology, 2020
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its ...
Xinmin Yang, Linbo Yao, Xianghui Fu, Rajarshi Mukherjee, Qing Xia, Monika A. Jakubowska, Pawel E. Ferdek, Wei Huang   +7 more
doaj   +1 more source

Multifocal High-Grade Pancreatic Precursor Lesions: A Case Series and Management Recommendations [PDF]

, 2019
Background: The risk of developing invasive cancer in the remnant pancreas after resection of multifocal high-grade pancreatic precursor lesions is not well known.
Carr, Rosalie A., Roch, Alexandra M., Schmidt, Christian Max, Soufi, Mazhar, Wu, Howard H., Yip-Schneider, Michele T.   +5 more
core   +1 more source

Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study

Frontiers in Pharmacology
BackgroundAcute pancreatitis (AP) is a common digestive disorder, with necrotizing pancreatitis (NP) occurring in 20% of cases. Long-term complications can include pancreatic exocrine and endocrine insufficiency, with gut microbiota (GM) playing a ...
Jiongdi Lu, Jiongdi Lu, Zhe Wang, Zhe Wang, Feng Cao, Feng Cao, Jia Li, Guofeng Ji, Guofeng Ji, Fei Li, Fei Li   +10 more
doaj   +1 more source

Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis

Cells, 2020
Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics.
Michael Chvanov, Svetlana Voronina, Xiaoying Zhang, Svetlana Telnova, Robert Chard, Yulin Ouyang, Jane Armstrong, Helen Tanton, Muhammad Awais, Diane Latawiec, Robert Sutton, David N. Criddle, Alexei V. Tepikin   +12 more
doaj   +1 more source