Results 21 to 30 of about 205,472 (169)

Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis—A Literature Review

Biomolecules
Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden.
Valborg Vang Poulsen, Amer Hadi, Mikkel Parsberg Werge, John Gásdal Karstensen, Srdan Novovic   +4 more
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Pain Management in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Frontiers in Medicine, 2021
Background: Pain management is an important priority in the treatment of acute pancreatitis (AP). Current evidence and guideline recommendations are inconsistent on the most effective analgesic protocol.
Wenhao Cai, Wenhao Cai, Fei Liu, Yongjian Wen, Chenxia Han, Manya Prasad, Qing Xia, Vikesh K. Singh, Robert Sutton, Wei Huang   +9 more
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Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway

Frontiers in Pharmacology, 2022
Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies.
Xinmin Yang, Linbo Yao, Mei Yuan, Xiaoying Zhang, Monika A. Jakubowska, Pawel E. Ferdek, Lei Dai, Jingyu Yang, Tao Jin, Lihui Deng, Xianghui Fu, Dan Du, Tingting Liu, David N. Criddle, Robert Sutton, Wei Huang, Wei Huang, Qing Xia   +17 more
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Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute pancreatitis

Frontiers in Endocrinology, 2022
BackgroundTo determine the impact of glucose levels at admission and during first week (early phase) on clinical outcomes in patients with acute pancreatitis (AP) and to investigate the relationship between stress hyperglycaemia (SHG) and ...
Xinmin Yang, Na Shi, Linbo Yao, Wenhua He, Ping Zhu, Sheyu Li, Sheyu Li, Lan Li, Yuying Li, Shiyu Liu, Lihui Deng, Tao Jin, Tingting Liu, Nonghua Lu, John A. Windsor, Robert Sutton, Yin Zhu, Qing Xia, Wei Huang   +18 more
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Time-Course Lipidomics of Ornithine-Induced Severe Acute Pancreatitis Model Reveals the Free Fatty Acids Centered Lipids Dysregulation Characteristics

Metabolites, 2023
The relationship between the type and intensities of lipids of blood and pancreas and the pathological changes in the pancreas during severe acute pancreatitis (SAP) remains unclear.
Jinxi Yang, Manjiangcuo Wang, Qi Qiu, Yan Huang, Yiqin Wang, Qianlun Pu, Na Jiang, Rui Wang, Li Wen, Xiaoying Zhang, Chenxia Han, Dan Du   +11 more
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Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq

Frontiers in Immunology
BackgroundMitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis.
Xiaozhou Xie, Xiaozhou Xie, Zheng Wang, Zheng Wang, Haoyu Zhang, Haoyu Zhang, Jiongdi Lu, Jiongdi Lu, Feng Cao, Feng Cao, Fei Li, Fei Li   +11 more
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Role of Seipin in Human Diseases and Experimental Animal Models

Biomolecules, 2022
Seipin, a protein encoded by the Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene, is famous for its key role in the biogenesis of lipid droplets and type 2 congenital generalised lipodystrophy (CGL2). BSCL2 gene mutations result in genetic
Yuying Li, Xinmin Yang, Linrui Peng, Qing Xia, Yuwei Zhang, Wei Huang, Tingting Liu, Da Jia   +7 more
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Hemoconcentration is associated with early faster fluid rate and increased risk of persistent organ failure in acute pancreatitis patients

JGH Open, 2020
Background Controversies existed surrounding the use of hematocrit to guide early fluid therapy in acute pancreatitis (AP). The association between hematocrit, early fluid therapy, and clinical outcomes in ward AP patients needs to be investigated ...
Tao Jin, Lan Li, Lihui Deng, Si Wen, Ruwen Zhang, Na Shi, Ping Zhu, Lan Lan, Ziqi Lin, Kun Jiang, Jia Guo, Tingting Liu, Anthony Philips, Xiaonan Yang, Vikesh K Singh, Robert Sutton, John A Windsor, Wei Huang, Qing Xia   +18 more
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Yinchenhao Decoction Protects Against Acute Liver Injury in Mice With Biliary Acute Pancreatitis by Regulating the Gut Microflora–Bile Acids–Liver Axis

Gastroenterology Research and Practice
Conclusions: These findings imply a potential link between gut microbiota dysbiosis and intrahepatic cholestasis in BAP-ALI mice and suggest that YCHD treatment may confer protection against BAP-ALI via the gut microflora–bile acids–liver axis.
Xianlin Zhao, Xiajia Wu, Qian Hu, Jiaqi Yao, Yue Yang, Meihua Wan, Wenfu Tang   +6 more
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Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine

Frontiers in Physiology, 2019
Pancreatic acinar cells require high rates of amino acid uptake for digestive enzyme synthesis, but excessive concentrations can trigger acute pancreatitis (AP) by mechanisms that are not well understood.
Xiaoying Zhang, Xiaoying Zhang, Tao Jin, Tao Jin, Na Shi, Linbo Yao, Xinmin Yang, Chenxia Han, Li Wen, Dan Du, Peter Szatmary, Rajarshi Mukherjee, Tingting Liu, Qing Xia, David N. Criddle, Wei Huang, Michael Chvanov, Robert Sutton   +17 more
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