Results 31 to 40 of about 254,687 (213)

The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis [PDF]

, 2018
A nonsense variant (p.W358X) of human pancreatic lipase related protein 2 (PNLIPRP2) is present in different ethnic populations with a high allele frequency.
Hegyi, Eszter, Hegyi, Peter, Lowe, Mark E, Nemeth, Balazs Csaba, Pesei, Zsofia Gabriella, Sahin-Toth, Miklos, Szentesi, Andrea, Szucs, Akos   +7 more
core   +2 more sources

Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis—A Literature Review

Biomolecules
Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden.
Valborg Vang Poulsen, Amer Hadi, Mikkel Parsberg Werge, John Gásdal Karstensen, Srdan Novovic   +4 more
doaj   +1 more source

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis [PDF]

, 2014
CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms.
Alkaade, Samer, Aloe, Amy, Amann, Stephen T., Anderson, Michelle A., Bahar, Ivet, Baillie, John, Banks, Peter A., Barmada, M. Michael, Brand, Randall E., Conwell, Darwin, Cote, Gregory, Gardner, Timothy B., Gelrud, Andres, General, Ignacio, Jung, Jinsei, Kienholz, Michelle L., LaRusch, Jessica, Lawrence, Christopher, Lee, Min Goo, Lewis, Michele D., North American Pancreatitis Study Group, Park, Hyun Woo, Romagnuolo, Joseph, Sandhu, Bimaljit, Slivka, Adam, Whitcomb, David C., Yadav, Dhiraj   +26 more
core   +4 more sources

Chronic pancreatitis

Southern Medical Journal, 1963
Chronic pancreatitis is caused most often by chronic excessive alcohol consumption. The disease can be diagnosed by investigations that measure function or assess morphology of the pancreas, thereby permitting a tailored management approach. In many patients, abdominal pain and steatorrhea can be managed effectively by enzyme supplementation, provided ...
openaire   +4 more sources

Src as the link between inflammation and cancer. [PDF]

, 2013
Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik, Hung ePham, Sandy eLiu, Stephen J Pandol, Stephen J Pandol   +4 more
core   +2 more sources

What should be measured and reported in clinical trials for the treatment of patients with acute pancreatitis? A study protocol for establishing a core outcome set

BMJ Open, 2023
Introduction Acute pancreatitis (AP) is characterised by inflammation of the exocrine pancreas, which potentially leads to local complications and organ failure resulting in significant morbidity and mortality.
Wei Huang, Ling Li, Xin Sun, Chen Hu, Lihui Deng, Ping Zhu, Qing Xia, Weiwei Chen, Yuxin Shen, Zhiyao Chen, Ziqi Lin, Qingyuan Tan   +11 more
doaj   +1 more source

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]

, 2012
Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C, Dawson, David, Dry, Sarah M, Gier, Belinda, Kirakossian, David, Matveyenko, Aleksey V   +5 more
core   +1 more source

The Diagnosis and Treatment of Local Complications of Acute Necrotizing Pancreatitis in China: A National Survey

Gastroenterology Research and Practice, 2021
Background. The optimal management strategy in acute necrotizing pancreatitis (ANP) is debated, and compliance with current guidelines in China is not known. In this study, we performed a national survey on this topic in China. Methods.
Xiaowu Dong, Wenjian Mao, Lu Ke, Lin Gao, Jing Zhou, Bo Ye, Gang Li, Anthony Phillips, Zhihui Tong, John Windsor, Weiqin Li, Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)   +11 more
doaj   +1 more source

Diagnosis of pancreatic disease in feline platynosomosis [PDF]

, 2017
Objectives: Platynosomum species are cat-specific parasitic trematodes that parasitize the biliary ducts and gall bladder. Due to the common connection to the major duodenal papilla of the pancreas and common bile ducts in addition to the periductal ...
Illanes, Oscar, Ketzis, Jennifer, Köster, Liza, Rajeev, Sreekumari, Shell, Linda   +4 more
core   +1 more source

Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq

Frontiers in Immunology
BackgroundMitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis.
Xiaozhou Xie, Xiaozhou Xie, Zheng Wang, Zheng Wang, Haoyu Zhang, Haoyu Zhang, Jiongdi Lu, Jiongdi Lu, Feng Cao, Feng Cao, Fei Li, Fei Li   +11 more
doaj   +1 more source