Results 31 to 40 of about 205,472 (169)

Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer

Frontiers in Pharmacology, 2021
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of diseases ...
Yongjian Wen, Yongjian Wen, Yongjian Wen, Wenhao Cai, Wenhao Cai, Jingyu Yang, Xianghui Fu, Lohitha Putha, Qing Xia, John A. Windsor, Anthony R. Phillips, Anthony R. Phillips, Joel D. A. Tyndall, Dan Du, Tingting Liu, Wei Huang, Wei Huang   +16 more
doaj   +1 more source

High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer

Frontiers in Immunology
BackgroundAminooctylamine (ANO1) plays an oncogenic role in various cancers. However. its role in pancreatic cancer (PC) has rarely been studied. This study investigated the prognostic value of ANO1 and its correlation with the tumor microenvironment ...
Guangnian Zhang, Zhihui Shu, Jun Yu, Jianshui Li, Pengsheng Yi, Bin Wu, Dawei Deng, Shu Yan, Yong Li, Dongmei Ren, Yifu Hou, Yifu Hou, Chuan Lan   +12 more
doaj   +1 more source

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Frontiers in Physiology, 2020
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its ...
Xinmin Yang, Linbo Yao, Xianghui Fu, Rajarshi Mukherjee, Qing Xia, Monika A. Jakubowska, Pawel E. Ferdek, Wei Huang   +7 more
doaj   +1 more source

Characterization of Duodenal Microbiota in Patients with Acute Pancreatitis and Healthy Controls [PDF]

, 2023
Meng-Qi Zhao, Meng-Yan Cui, Qiao-Li Jiang, Jingjing Wang, Miao-Yan Fan, Yingying Lu   +5 more
openalex   +1 more source

Klebsiella predominance in peripancreatic microbial spectrum is associated with the severity of infected pancreatic necrosis

BMC Infectious Diseases
Background Infectious pancreatic necrosis (IPN) is associated with the prognosis of acute pancreatitis (AP). The correlation between microbial diversity in the peripancreatic region and AP severity remains unclear.
Xiaolan Guo, Yao Xu, Kaiwei Li, Jingzhu Zhang, Zhihui Tong, Weiqin Li, Donghuang Hong   +6 more
doaj   +1 more source

Clinical characteristics and prognosis of older adult patients with necrotizing pancreatitis: a single center retrospective study

Journal of Pancreatology
Background:. Acute pancreatitis (AP) is a common condition encountered during clinical practice; 20% of patients have pancreatic necrosis, and the mortality is high.
Yue Wu, JiongDi Lu, Feng Cao, Fei Li
doaj   +1 more source

Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis

Cells, 2020
Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics.
Michael Chvanov, Svetlana Voronina, Xiaoying Zhang, Svetlana Telnova, Robert Chard, Yulin Ouyang, Jane Armstrong, Helen Tanton, Muhammad Awais, Diane Latawiec, Robert Sutton, David N. Criddle, Alexei V. Tepikin   +12 more
doaj   +1 more source

Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets

Toxics
Acute pancreatitis (AP), induced by tetracycline, a widely used antibiotic, poses significant clinical and toxicological challenges, yet its molecular mechanisms remain unclear.
Hang Lei, Yimao Wu, Wenjun Ma, Jiaqi Yao, Pengcheng Zhang, Yong Tian, Yuhong Jiang, Zhijun Xie, Lv Zhu, Wenfu Tang   +9 more
doaj   +1 more source

Coagulopathy and acute pancreatitis: pathophysiology and clinical treatment

Frontiers in Immunology
Coagulopathy is a critical pathophysiological mechanism of acute pancreatitis (AP), arising from the complex interplay between innate immune, endothelial cells and platelets.
Lan Li, Lan Li, Qingyuan Tan, Qingyuan Tan, Xueying Wu, Xiaowen Mou, Xiaowen Mou, Ziqi Lin, Tingting Liu, Wei Huang, Wei Huang, Lihui Deng, Tao Jin, Tao Jin, Qing Xia, Qing Xia   +15 more
doaj   +1 more source

Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study

Frontiers in Pharmacology
BackgroundAcute pancreatitis (AP) is a common digestive disorder, with necrotizing pancreatitis (NP) occurring in 20% of cases. Long-term complications can include pancreatic exocrine and endocrine insufficiency, with gut microbiota (GM) playing a ...
Jiongdi Lu, Jiongdi Lu, Zhe Wang, Zhe Wang, Feng Cao, Feng Cao, Jia Li, Guofeng Ji, Guofeng Ji, Fei Li, Fei Li   +10 more
doaj   +1 more source