Results 31 to 40 of about 472,362 (405)

Pathophysiology of acute experimental pancreatitis: Lessons from genetically engineered animal models and new molecular approaches [PDF]

, 2005
The incidence of acute pancreatitis is growing and worldwide population-based studies report a doubling or tripling since the 1970s. 25% of acute pancreatitis are severe and associated with histological changes of necrotizing pancreatitis. There is still
Anne Barbara Tietz, Arnush M, Bhagat L, Bhatia M, Bhatia M, Bockman DE, Burkhard Göke, Claus Schäfer, Demols A, Ebert MP, Frossard JL, Gardner JD, Gerard C, Grady T, Grisham M, Gu D, Gukovskaya AS, Gukovsky I, Hahm KB, Halangk W, Halangk W, Korc M, Lee MS, Leser HG, Massague J, Meda P, Norman J, Ohnishi H, Ohnishi H, Ohnishi H, Roberts AB, Saluja A, Schafer C, Schafer C, Schmid RM, Song AM, Steinle A, Van Acker GJD, Vogelmann R   +38 more
core   +1 more source

Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

Microbiome, 2021
Background The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of heparanase in acute pancreatitis remain poorly
Yuanyuan Lei, Li Tang, Shuang Liu, Shiping Hu, Lingyi Wu, Yaojiang Liu, Min Yang, Shengjie Huang, Xuefeng Tang, Tao Tang, Xiao-yan Zhao, I. Vlodavsky, Shuo Zeng, Bo Tang, Shiming Yang   +14 more
semanticscholar   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium [PDF]

, 2013
Several deleterious intra-acinar phenomena are simultaneously triggered on initiating acute pancreatitis. These culminate in acinar injury or inflammatory mediator generation in vitro and parenchymal damage in vivo. Supraphysiologic caerulein is one such
A Gnoni, A Pace, A Sharma, AJ Hietaranta, AK Saluja, AK Saluja, AS Gukovskaya, B Han, B Han, B Hofbauer, B Kruger, C Schafer, Catherine J. Baty, CH Kubisch, Chandra Durgampudi, Chathur Acharya, DN Criddle, Donna B. Stolz, EC Thrower, EM Parker, F Gorelick, F Mooren, F Nozu, G Lynch, H Weber, HK Baumgartner, I Gukovsky, I Gukovsky, I Samuel, JA Tapia, JA Williams, Jenny Karlsson, JV Gerasimenko, KA Muili, Krutika Patel, L Fischer, L Orlichenko, Lidiya Orlichenko, LJ Christopher, LJ Lombardo, LS Orlichenko, M Sendler, MS O'Konski, OA Mareninova, OH Petersen, Pawan Noel, PC Redondo, Rachel Cline, Ram Narayan Trivedi, RD Duan, RR Torgerson, RR Torgerson, S Kawabata, S Navina, Sarah Navina, SD Waterford, SG Weller, SJ Pandol, Sohail Z. Husain, Stuart E. Dryer, SZ Husain, SZ Husain, T Eley, T Grady, T Grady, V Sancho, Vijay P. Singh, Vivek Mishra, VP Singh, VP Singh, VP Singh, VP Singh, Y Tsunoda   +72 more
core   +5 more sources

Plasma metagenomic next-generation sequencing of microbial cell-free DNA detects pathogens in patients with suspected infected pancreatic necrosis

BMC Infectious Diseases, 2022
Background Infected pancreatic necrosis (IPN) is a life-threatening complication of acute pancreatitis (AP). Timely diagnosis of IPN could facilitate appropriate treatment, but there is a lack of reliable non-invasive screening tests.
Donghuang Hong, Peng Wang, Jingzhu Zhang, Kaiwei Li, Bo Ye, Gang Li, Jing Zhou, Zhihui Tong, Lu Ke, Songjing Shi, Weiqin Li   +10 more
doaj   +1 more source

ACG Clinical Guideline: Chronic Pancreatitis.

American Journal of Gastroenterology, 2020
Chronic pancreatitis (CP) is historically defined as an irreversible inflammatory condition of the pancreas leading to varying degrees of exocrine and endocrine dysfunction.
T. Gardner, D. Adler, C. Forsmark, B. Sauer, Jason R. Taylor, D. Whitcomb   +5 more
semanticscholar   +1 more source

Essential Role of Lyn in Fibrosis. [PDF]

, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Birtolo, Chiara, Chheda, Chintan, Cirulli, Vincenzo, Gugliotta, Gabriele, Lewis, Michael S, Liu, Sandy T, Pandol, Stephen J, Pham, Hung, Ptasznik, Andrzej, Rodriguez, Maria D, Yang, Wendy   +10 more
core   +2 more sources

Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk [PDF]

, 2002
Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two ...
Aufenanger, Johannes, Bertsch, Thomas, Fassbender, Klaus, Quintel, Michael, Samman, Michael, Zimmer, Wilma   +5 more
core   +1 more source

2019 WSES guidelines for the management of severe acute pancreatitis

World Journal of Emergency Surgery, 2019
Although most patients with acute pancreatitis have the mild form of the disease, about 20–30% develops a severe form, often associated with single or multiple organ dysfunction requiring intensive care.
A. Leppäniemi, M. Tolonen, A. Tarasconi, H. Segovia-Lohse, E. Gamberini, A. Kirkpatrick, C. Ball, N. Parry, M. Sartelli, D. Wolbrink, H. van Goor, G. Baiocchi, L. Ansaloni, W. Biffl, F. Coccolini, S. di Saverio, Y. Kluger, E. Moore, F. Catena   +18 more
semanticscholar   +1 more source

Organ Failure Due to Systemic Injury in Acute Pancreatitis.

Gastroenterology, 2019
Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure, which is seen in approximately 20% of all cases of acute pancreatitis and defines "severe acute pancreatitis." Organ ...
P. Garg, Vijay P. Singh
semanticscholar   +1 more source