Results 31 to 40 of about 1,068,976 (306)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Efficacy of baloxavir marboxil against bovine H5N1 virus in mice

Nature Communications
Since the first detection of highly pathogenic avian influenza (HPAI) H5N1 (clade 2.3.4.4b) in U.S. dairy cattle in early 2024, the virus has spread rapidly, posing a major public health concern as the number of human cases continues to rise.
Maki Kiso, Ryuta Uraki, Seiya Yamayoshi, Yoshihiro Kawaoka   +3 more
doaj   +1 more source

Pandemic Preparedness: The Importance of Adequate Immune Fitness

Journal of Clinical Medicine, 2022
Pandemic preparedness is an important issue in relation to future pandemics. The two studies described here aimed to identify factors predicting the presence and severity of coronavirus disease 2019 (COVID-19) symptoms. The CLOFIT study comprised an online survey among the Dutch population (n = 1415). Perceived immune fitness before the pandemic (2019)
Pantea Kiani, Jessica Balikji, Aletta D. Kraneveld, Johan Garssen, Gillian Bruce, Joris C. Verster   +5 more
openaire   +5 more sources

The American Preparedness Project: Executive Summary: Where the US Public Stands in 2011 on Terrorism, Security, and Disaster Preparedness [PDF]

, 2011
Ten years after the tragic events of September 11, 2001, America is, in some aspects, a different country. Significant portions of the federal budget over the past decade have been spent on enhancing preparedness and security on the home front, and ...
National Center for Disaster Preparedness
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Informing social media analysis for public health: a cross-sectional survey of professionals

Archives of Public Health
Background During the COVID-19 pandemic, the field of infodemic management has grown in response to urgent global need. Social listening is the first step in managing the infodemic, and many organizations and health systems have implemented processes ...
Becky K. White, Elisabeth Wilhelm, Atsuyoshi Ishizumi, Surangani Abeyesekera, Alhassan Pereira, Brian Yau, Aleksandra Kuzmanovic, Tim Nguyen, Sylvie Briand, Tina D. Purnat   +9 more
doaj   +1 more source

Public views of the UK media and government reaction to the 2009 swine flu pandemic [PDF]

, 2010
<p>Background: The first cases of influenza A/H1N1 (swine flu) were confirmed in the UK on 27th April 2009, after a novel virus first identified in Mexico rapidly evolved into a pandemic.
Smith, Emily, Smith Emily, Hilton, Shona, Hilton Shona, Shona Hilton, Emily Smith   +5 more
core   +2 more sources

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Mental health consequences of COVID-19: a nationally representative cross-sectional study of pandemic-related stressors and anxiety disorders in the USA

BMJ Open, 2021
Objective To document the prevalence of anxiety disorders in the USA during the COVID-19 pandemic.Design A cross-sectional analysis.Setting A nationally representative sample in the USA between 31 March and 13 April 2020.Participants 1450 English ...
Sandro Galea, Salma M Abdalla, Catherine K Ettman, Gregory H Cohen   +3 more
doaj   +1 more source

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

Advanced Healthcare Materials, EarlyView.
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang, Shunmuga Nathan Shunmuga Nainar, Bing‐Han Zhuang, Shun‐Mao Yang, Hong‐Cheu Lin, Yang‐Hsiang Chan   +5 more
wiley   +1 more source