Results 111 to 120 of about 318,454 (302)

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Pandemic Fatigue [PDF]

Home Healthcare Now, 2021
openaire   +4 more sources

The COVID-19 vaccination campaign in Switzerland and its impact on disease spread

Epidemics
We analyse infectious disease case surveillance data to estimate COVID-19 spread and gain an understanding of the impact of introducing vaccines to counter the disease in Switzerland.
M. Bekker-Nielsen Dunbar, L. Held
doaj   +1 more source

Bayesian Best-Arm Identification for Selecting Influenza Mitigation Strategies

, 2018
Pandemic influenza has the epidemic potential to kill millions of people. While various preventive measures exist (i.a., vaccination and school closures), deciding on strategies that lead to their most effective and efficient use remains challenging.
C Fraser, C Jennison, Catharine Paules, DJ Watts, DL Chao, DL Chao, E Even-Dar, E Kaufmann, I Dorigatti, J Medlock, JO Lloyd-Smith, JT Wu, L Fumanelli, L Willem, M Enserink, M Hartfield, ME Halloran, NE Basta, NM Ferguson, P Libin, R Herbert, S Bubeck, S Bubeck, S Eubank, T Britton, TC Germann, WB Powell   +26 more
core   +2 more sources

Pandemic paediatrics [PDF]

British Dental Journal, 2020
Fakhruddin, K. S., Ngo, H. C., Samaranayake, L.   +2 more
openaire   +2 more sources

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Book review: Divided nations: why global governance is failing and what we can do about it [PDF]

, 2013
"Divided Nations: Why Global Governance is Failing and What We Can Do About It." Ian Goldin. Oxford University Press. March 2013. --- Humanity today faces a number of international challenges which spill over national boundaries: climate change, finance,
Hearson, Martin
core  

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

Advanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim, Seoa Kim, Erik A. Wu, Darren H. S. Tan, Shawn Peng, Xiaolin Li   +5 more
wiley   +1 more source

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Nature Communications
Coronaviruses have caused three major endemics in the past two decades. Alarmingly, recent identification of novel zoonotic coronaviruses that caused human infections suggests the risk of future coronavirus outbreak caused by spillover infection from ...
Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang, Yuxin Hou, Xiaoyan Xia, Lei Wang, Xinyue Deng, Yifei Wang, Qingquan Li, Lianzhao Du, Yuanchen Liu, Minmin Zhou, Hoi Ting Wong, Jiaheng Hu, Huan Liu, Bingjie Hu, Dong Wang, Jingyi Su, Yuying Pan, Yongtao Ye, Yan Chen, Zhen Fang, Ziyi Xia, Yue Chai, Jialu Shi, Yang Wang, Tianrenzheng Zhu, Honglei Zhang, Shuofeng Yuan, Jie Zhou, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Chunfu Xu, Jian Lei, Shengyong Yang, Hin Chu   +36 more
doaj   +1 more source