Results 91 to 100 of about 186,683 (267)
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
Advanced Science, EarlyView.This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu +7 more
wiley +1 more source
Human Resources for HealthBackground In Canada and internationally, health systems have experienced rising healthcare staffing shortages in recent years. Specifically, this study seeks to analyse evidence on the causes and effects of hospital nursing shortages, to consider ...
David Jones, Sara Allin
doaj +1 more source
International Treaty on Global Pandemics to Face Future Pandemics
Informaciâ i InnovaciiThe problems and challenges confronting the global governance of international public health are on the rise, emphasizing the critical need for stronger international collaboration and resource-sharing to combat health threats.
S. K. Varshney, N. K. Prasanna
doaj +1 more source
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source
Southern Spaces, 2023 Former Centers for Disease Control branch chief, Daniel Pollock, reflects on the CDC\'s failure in preparing for and responding to the COVID-19 pandemic.
doaj
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
Evolving Dynamics of Whole-Genome Influenza A/H3N2 Viruses Isolated in Cameroon
Advances in VirologyConclusions: These results highlight the evolutionary nature of the human influenza virus.
Desmon Toutou Tsafack +9 more
doaj +1 more source
The COVID-19 vaccination campaign in Switzerland and its impact on disease spread
EpidemicsWe analyse infectious disease case surveillance data to estimate COVID-19 spread and gain an understanding of the impact of introducing vaccines to counter the disease in Switzerland.
M. Bekker-Nielsen Dunbar, L. Held
doaj +1 more source