Results 81 to 90 of about 186,683 (267)

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Lonicera japonica‐Derived Nanovesicles Ameliorate Acute Lung Injury by Suppressing Neutrophil Extracellular Traps Formation in Mice

Advanced Healthcare Materials, EarlyView.
(A) Isolation and purification of LDNVs. (B) Establishment of the ALI model and LDNVs delivery. (C) Therapeutic mechanisms of LDNVs in treating ALI. This scheme figure was drawn by Figdraw, ID: IUIIO21222. ABSTRACT Acute lung injury (ALI) is a lethal respiratory disease.
Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin   +10 more
wiley   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia

npj Antimicrobials and Resistance
Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections.
Victor A. Medina, Angela S. García-Vega, Fernando Rodríguez, Enmanuel S. Triviño-García, Jaime A. Robledo, Aura L. Leal, Julián C. Galvis, Luis F. Reyes, Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR), Iruka N. Okeke, Natacha Couto, Emmanuelle A. Kumaran, Georgina Lewis-Woodhouse, Silvia Argimon, Stefany A. Arevalo, Anthony P. Underwood, Xavier Fargetton, David M. Aanensen, Maria P. Donado-Godoy   +18 more
doaj   +1 more source

Tunable‐Threshold UV Dosimetry With Programmable Luminescent Tags via Oxygen‐Mediated Room‐Temperature Phosphorescence

Advanced Materials Technologies, EarlyView.
A fully organic UV threshold dosimeter is developed by exploiting the oxygen‐sensitive room‐temperature phosphorescence of a purely organic emitter in a polymer matrix. Upon reaching a specific cumulative UV dose, photochemical oxygen depletion triggers a sharp, high‐contrast emission.
Tim Achenbach, Paul‐Anton Will, Karl Sebastian Schellhammer, Sebastian Reineke   +3 more
wiley   +1 more source

Epicore: An infectious disease surveillance tool for field-based verification of public health events

International Journal of Infectious Diseases, 2020
L. Goodwin, E. Cohn, J. Mantero, N. Divi, M. Libel, J. Brownstein   +5 more
doaj   +1 more source

Pathogenicity, virological features, and immune evasion of SARS-CoV-2 JN.1-derived variants including JN.1.7, KP.2, KP.3, and KP.3.1.1

Nature Communications
KP.3.1.1 became a dominant successor to JN.1 by the second half of 2024 but the intrinsic pathogenicity and virological feature of KP.3.1.1 remain incompletely understood.
Jialu Shi, Xiaoyu Zhao, Xiaohui Jin, Jiayan Li, Yuanchen Liu, Huan Liu, Ye-Fan Hu, Zhe Chen, Yuxin Xiao, Lei Wang, Yajie Wang, Yixin He, Yue Chai, Bingjie Hu, Huiping Shuai, Yang Wang, Xiangnan Li, Shujun Jiang, Yanliang Zhang, Xiaojuan Zhang, Wan-Mui Chan, Lin-Lei Chen, Jian-Piao Cai, Baokun Sui, Honglei Zhang, Dong Yang, Longchao Zhu, Shuofeng Yuan, Jie Zhou, Jian-Dong Huang, Kwok-Yung Yuen, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Bao-Zhong Zhang, Qiao Wang, Maozhou He, Lei Sun, Pengfei Wang, Hin Chu   +38 more
doaj   +1 more source

High immunity and low mortality after Omicron and mass event in Cameroon despite low vaccination

Journal of Public Health in Africa
Background: Little is known about the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity in African communities. Aim: We evaluated changes in anti-SARS-CoV-2 antibodies, mortality and vaccination status in Cameroon ...
Yap Boum II, Lucrece Matchim, Dominique K. Guimsop, Bongkiyung D. Buri, Lisa M. Bebell, Yuya S.F. Jaudel, Fai K.G. Njuwa, Daniel B. Danirla, Eric Youm, Rodrigue Ntone, Claudric Roosevelt Tchame, Dora Tchiasso, Rachelle Essaka, Justin B. Eyong, Audrey Ngosso, Herwin Nanda, Nsaibirni R. Fondze, Mark Ndifon Ndifon, Lucrèce Eteki, Yonta F.C. Ghislain, Bruno Yannick Eyenga Messi, Hamadou Moustapha, Moustafa Hamdja, René Ghislain Essomba, Nadia Mandeng, Tamakloe A.K. Modeste, Anne-Cécile Zoung-Kani Bisseck, Sara Irène Eyangoh, Richard Njouom, Marie Claire Okomo, Linda Esso, Epee Emilienne, Georges-Alain Etoundi Mballa   +32 more
doaj   +1 more source