Results 101 to 110 of about 189,819 (265)

Global excess tuberculosis mortality during COVID-19: a country-level modeling study of policy and development correlates

BMC Public Health
Background The COVID-19 pandemic disrupted global tuberculosis (TB) control efforts, leading to a surge in TB-related excess mortality, particularly in low- and middle-income countries.
Hamed Karami, Svenn-Erik Mamelund, Alexandra Smirnova, Gerardo Chowell   +3 more
doaj   +1 more source

Global Burden and Temporal Trends of Early‐Onset Tracheal, Bronchial, and Lung Cancer: An Analysis of GLOBOCAN 2022 and GBD 2023 Data

Advanced Science, EarlyView.
This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian, Weihao Zhang, Yao Lu, Bruce F. O'Hara, Jingjing Hu, Hanqi Feng, Jing Di, Lei Zhang, Xueying Yang   +8 more
wiley   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Drivers and barriers of seasonal influenza vaccination 2015/16 & 2019/20 to 2022/23 - a survey on why most Norwegians don’t get the flu vaccine

BMC Public Health
Background This study aimed to explore the reasons adults in the general population, influenza risk groups (RGs) and health care workers (HCWs) in Norway give for their vaccination choices and whether these reasons vary between groups or over time in ...
Birgitte Klüwer, Kjersti Margrethe Rydland, Svenn-Erik Mamelund, Rebecca Nybru Gleditsch   +3 more
doaj   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Molecular characterization of human respiratory syncytial virus in Mexico (season 2023–2024) through whole-genome sequencing

Scientific Reports
Human respiratory syncytial virus (hRSV) is a one of major cause of severe acute respiratory infection (SARI) in young children and the elderly. Because genomic surveillance of hRSV is essential to understand viral evolution and the genetic variation ...
Evelyn Rivera-Toledo, Fidencio Mejıa-Nepomuceno, Enrique Mendoza-Ramırez, America Vera-Jimenez, Eduardo Becerril-Vargas, Victor Hugo Ahumada-Topete, Manuel Castillejos-Lopez, Francisco Bernardo Perez-Orozco, Geovanni Benitez, Miguel Ángel Salazar-Lezama, Josue Daniel Cadeza-Aguilar, Emma Garcia-Colin, Claudia Garrido-Galindo, Justino Regalado-Pineda, John P. Collins, Xiang-Jun Lu, J. Kenneth Wickiser, Joel Armando Vazquez-Perez   +17 more
doaj   +1 more source

The Invisible Pandemics [PDF]

Academic Psychiatry, 2021
openaire   +2 more sources

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

La casa de papel: A pandemic in a pandemic

Journal of Affective Disorders, 2020
Amerio A., Odone A., Aguglia A., Gianfredi V., Bellini L., Bucci D., Gaetti G., Capraro M., Salvati S., Serafini G., Signorelli C., Amore M., Ghaemi S. N.   +12 more
openaire   +4 more sources

Atomically Dispersed Fe‐Modified SnS for Sn‐Centered Peroxymonosulfate Activation Toward Acetaminophen Degradation

Advanced Science, EarlyView.
Atomically dispersed Fe regulates the local electronic environment and surface properties of SnS, while PMS preferentially coordinates to Sn through Sn–O interaction. Fe incorporation further enhances the Sn–OPMS interfacial interaction, facilitating Sn‐centered PMS activation and the generation of SO4•−/•OH for APAP degradation, thereby clarifying the
Shuhui Liu, Yantao Wang, Ya Liu, Jingkai Lin, Shaobin Wang, Wenjie Tian   +5 more
wiley   +1 more source