Results 101 to 110 of about 55,287 (292)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Design issues in the British Household Panel Study [PDF]
, 1991 The British Household Panel Study is the largest single project ever funded by the UK Economic and Social Research Council. Housed in the ESRC's Centre on Micro-social Change in Britain at the University of Essex, the BHPS will comprise an initial 5000 ...
Buck, Nick +6 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Panel Conditioning : Wirkungsmechanismen und Konsequenzen wiederholter Befragungen
, 2014 Forscher, die mit Paneldaten arbeiten, gehen in der Regel davon aus, dass beobachtete Veränderungen abgefragter Einstellungen und Verhaltensweisen ausschließlich tatsächlichen Veränderungen entsprechen, die auch unabhängig von ihrer wiederholten Messung ...
Bergmann, Michael
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Motivated Underreporting: Filter Questions and Panel Conditioning - Wave 1 & Wave 2.
, 2013 This study examines underreporting in response to filter questions. Respondents were randomly assigned to three different formats of filter and follow-up questions.
Elshout, S. (CentERdata)
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
A Closer Look at Web Questionnaire Design.
This dissertation deals with the design of online questionnaires and its consequences for data quality: what is the effect of the number of items placed on a screen, the response categories, layout choices et cetera.
Toepoel, V.
core
Power Conditioning Unit - solar panel simulator test report
, 1969 A study was performed to determine if the ALSEP Power Conditioning Unit (PCU) is compatible with a solar panel array.prepared by R ...
Howell, R.
core