Results 111 to 120 of about 55,287 (292)

Understanding panel conditioning: an examination of social desirability bias in self-reported height and weight in panel surveys using experimental data

, 2011
Typically reliant on self-reports from panel data, a growing body of literature suggests that relative body weight can have negative effects on labour market outcomes.
Uhrig, S C Noah, Uhrig, SC Noah
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Second-order conditioning.

, 2014
Empirical (original measurement units) and simulated results during second-order conditioning test. Left panel reproduces the group mean response rates to the click across 4-trial blocks during test, adapted from Holland and Rescorla's Experiment 1 [57].
Dómhnall J. Jennings (603061), Esther Mondragón (603059), Jonathan Gray (5659951), Charlotte Bonardi (148275), Eduardo Alonso (603060)   +4 more
core   +1 more source

Natural Disasters and Development Thresholds: Infrastructure, Nonlinearity, and Economic Resilience

Systems
Natural disasters pose major challenges to economic development, yet empirical evidence on their growth effects remains mixed. This study examines whether the macroeconomic impact of disasters depends on infrastructure development, using electricity ...
Keisuke Kokubun
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Simulation and Experimental Validation of a 1D Cabin Thermal Model for Electric Trucks with Enhanced Insulation and Heating Panels

World Electric Vehicle Journal
To reduce emissions in the existing transportation system and lower carbon dioxide (CO2) output, battery electric vehicles (BEVs) offer a promising approach due to their higher energy efficiency. However, their driving range still falls short compared to
Imre Gellai, Milán Kardos, Mirza Popovac, Dragan Šimić   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Development of a perforated panel for acoustic conditioning based on Colombian guadua fiber (Guadua angustifolia Kunth)

, 2018
The present research is about the practical implementation of a perforated panel for acoustic conditioning, manufactured with guadua, a typical Colombian fiber. The developed panel is checked for its acoustic conditioning properties.
Paez Soto, Dario Alfonso, Herrera Fernandez, Luis Jorge, Acosta Agudelo, Oscar Esneider, Garcia Bustos, Shymmy Wilbermer, Herrera Martinez, Marcelo   +4 more
core  

Efficient Power Conditioning: Enhancing Electric Supply for Small Satellite Missions

Aerospace
Electric power supply (EPS) is the heart of any aerospace mission and plays an important role in improving the performance and service lifetime of spacecraft. It generates, converts, stores, and distributes power to different voltage levels.
Shoaib Ahmed Khan, Anwar Ali, Mustafa Tahir, Zou Tao   +3 more
doaj   +1 more source