Results 81 to 90 of about 30,495,821 (312)
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Institutional quality, aid flows, and malaria burden: a geospatial analysis of sub-Saharan Africa
Malaria JournalBackground Malaria remains a major public health challenge in sub-Saharan Africa, accounting for approximately 95 percent of global malaria deaths despite extensive interventions.
Caroline Namubiru
doaj +1 more source
Analysis of Advertisement Financial Efficiency in Pharmaceutical Sphere
Наукові записки НаУКМА: Економічні науки, 2017 This paper defines the main trends of pharmaceutical market development in Ukraine and presents the most common measures of the demand stimulation for pharmaceutical products, primarily advertisement.
Pervin Dadashova
doaj +1 more source
Identification and Estimation of Nonlinear Dynamic Panel Data Models with Unobserved Covariates [PDF]
This paper considers nonparametric identification of nonlinear dynamic models for panel data with unobserved voariates. Including such unobserved covariates may control for both the individual-specific unobserved heterogeneity and the endogeneity of the ...
Ji-Liang Shiu, Yingyao Hu
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Panel Data Econometrics in R: The plm Package [PDF]
Panel data econometrics is obviously one of the main fields in the profession, but most of the models used are difficult to estimate with R. plm is a package for R which intends to make the estimation of linear panel models straightforward.
Giovanni Millo, Yves Croissant
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Split-panel jackknife estimation of fixed-effect models [PDF]
We propose a jackknife for reducing the order of the bias of maximum likelihood estimates of nonlinear dynamic fixed-effect panel models. In its simplest form, the half-panel jackknife, the estimatorisjust 2θˆ−θ1/2,where θˆ!istheMLEfromthefullpaneland θ1/
DHAENE, Geert, JOCHMANS, Koen
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
GM Estimation of Higher Order Spatial Autoregressive Processes in Panel Data Error Component Models [PDF]
This paper presents a generalized moments (GM) approach to estimating an R-th order spatial regressive process in a panel data error component model. We derive moment conditions to estimate the parameters of the higher order spatial regressive process ...
Harald Badinger, Peter Egger
core