Results 1 to 10 of about 18,139 (120)
Glutamate-pantothenate pathway promotes antibiotic resistance of Edwardsiella tarda
Frontiers in Microbiology, 2023 Although cellular metabolic states have been shown to modulate bacterial susceptibility to antibiotics, the interaction between glutamate (Glu) and chloramphenicol (CAP) resistance remains unclear because of the specificity of antibiotics and bacteria ...
Bei-bei Yan +10 more
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Pharmaceuticals, 2023 The term neurodegeneration with brain iron accumulation (NBIA) brings together a broad set of progressive and disabling neurological genetic disorders in which iron is deposited preferentially in certain areas of the brain. Among NBIA disorders, the most
Mónica Álvarez-Córdoba +13 more
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Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA [PDF]
Open Biology, 2012 Biosynthesis of coenzyme A (CoA) requires a five-step process using pantothenate and cysteine in the fission yeast Schizosaccharomyces pombe. CoA contains a thiol (SH) group, which reacts with carboxylic acid to form thioesters, giving rise to acyl ...
Takahiro Nakamura +3 more
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Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. [PDF]
PLoS ONE, 2013 Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization.
Christina Spry +6 more
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Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target
International Journal for Parasitology: Drugs and Drug Resistance, 2023 Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug targets
Vanessa M. Howieson +11 more
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Frontiers in Cellular and Infection Microbiology, 2020 Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic.
Hailey S. Butman +3 more
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MicrobiologyOpen, 2020 Pantothenate is an indispensable vitamin precursor of the synthesis of coenzyme A (CoA), a key metabolite required in over 100 metabolic reactions. β‐Alanine (β‐ala) is an indispensable component of pantothenate.
Mariana López‐Sámano +6 more
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Eye of the Tiger Sign in Pantothenate Kinase-Associated Neurodegeneration
Case Reports in Radiology, 2021 Pantothenate kinase-associated neurodegeneration (PKAN) is a rare disorder associated with brain iron accumulation caused by a recessive mutation in pantothenate kinase 2 gene (PANK2).
S. Choayb +5 more
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Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models. [PDF]
PLoS ONE, 2018 In cells, phosphorylation of pantothenic acid to generate phosphopantothenic acid by the pantothenate kinase enzymes is the first step in coenzyme A synthesis.
Daniel Elbaum +7 more
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Biomolecules, 2021 Malaria parasites require pantothenate from both human and mosquito hosts to synthesize coenzyme A (CoA). Specifically, mosquito-stage parasites cannot synthesize pantothenate de novo or take up preformed CoA from the mosquito host, making it essential ...
Raquel M. Simão-Gurge +8 more
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