Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]
Int J Anal ChemHeroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M +4 more
europepmc +2 more sources
Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis. [PDF]
PLoS ONE, 2013 The benzylisoquinoline alkaloid papaverine, synthesized in low amount in most of the opium poppy varieties of Papaver somniferum, is used as a vasodilator muscle relaxant and antispasmodic.
Sumya Pathak +6 more
doaj +1 more source
Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation
iScience, 2023 Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li +8 more
doaj +1 more source
Three-Stage Prelaminated Radial Forearm Flap for Total Auricular Reconstruction Following Scalp Avulsion Injury. [PDF]
Clin Case RepABSTRACT Loss of mastoid skin and temporoparietal fascia after complete scalp avulsion precludes conventional ear reconstruction. We report a total auricular reconstruction using a remote, prelaminated radial‐forearm flap. A 42‐year‐old woman with prior scalp avulsion and right ear amputation underwent (1) 200‐mL forearm expansion, (2) autogenous ...
Liang B, Xue Y, Zhang W, Lan J.
europepmc +2 more sources
Inhibitory Mechanism of Papaverine on Carbachol-Induced Contraction in Bovine Trachea
Journal of Pharmacological Sciences, 2005 We have demonstrated that the relaxing mechanism of papaverine in phasic muscles such as ileum, urinary bladder, and uterus is different from tonic muscles such as aorta. In this study, we examined the inhibitory mechanism of papaverine on carbachol (CCh)
Takeharu Kaneda +5 more
doaj +1 more source
Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein. [PDF]
PLoS ONE, 2016 OBJECTIVE:Papaverine is used to prevent vasospasm in human saphenous veins (HSV) during vein graft preparation prior to implantation as a bypass conduit.
Kyle M Hocking +5 more
doaj +1 more source
Novel Papaverine Metal Complexes with Potential Anticancer Activities
Molecules, 2020 Cancer is one of the leading causes of death worldwide. Although several potential therapeutic agents have been developed to efficiently treat cancer, some side effects can occur simultaneously.
Ahmed Gaber +4 more
doaj +1 more source
Indian Journal of Urology, 2021 Drug-induced priapism is well known and papaverine is the most common drug known to cause priapism. Drotaverine, an analog of papaverine, is used extensively to treat Colicky pain. We report the first case of drotaverine.induced priapism.
Ajay Shyam Kanbur +2 more
doaj +1 more source
Simplified Assessment of the Index of Microvascular Resistance
Journal of Interventional Cardiology, 2021 Background. To validate a simplified invasive method for the calculation of the index of microvascular resistance (IMR). Methods. This is a prospective, single-center study of patients with chronic coronary syndromes presenting with nonobstructive ...
Monika Kodeboina +15 more
doaj +1 more source
Non-Classical Effects of the cAMP Accumulation Activators In Vivo [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Wound-healing dipyridamole- and papaverine-based aerosols (D1/D2) as activators of the accumulation of cyclic adenosine monophosphate are promising drugs that can accelerate wound healing in wound processes of various origins.
Artur Martynov +4 more
doaj +1 more source